SRrp35 suppresses cell proliferation and malignancy in hepatocellular carcinoma
SRrp35 suppresses cell proliferation and malignancy in hepatocellular carcinoma
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DOI：
10.1111/hepr.12493
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发表时间：
2015-03
影响因子：
4.2
通讯作者：
Yandong Li;Yun Lin;Qun Li;Yong Gao
中科院分区：
文献类型：
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作者：
Yandong Li;Yun Lin;Qun Li;Yong Gao
已知富含丝氨酸/精氨酸（SR）的蛋白质参与前体mRNA的选择性剪接、RNA代谢和癌症发展。SRrp 35是该家族的成员，其在剪接调节中拮抗经典SR蛋白。然而，SRRP 35在癌症中的功能至今仍不清楚。本研究旨在探讨SRrp 35在肝细胞癌（HCC）中的功能。
Serine/arginine‐rich (SR) proteins are known to be involved in alternative pre‐mRNA splicing, RNA metabolism and cancer development. SRrp35 is a member of this family that antagonizes classical SR proteins in the regulation of splicing. However, the function of SRRP35 in cancer remains unclear to date. This study aims to investigate SRrp35 function in hepatocellular carcinoma (HCC).