Usefulness of contrast-enhanced CT in the evaluation of depth of invasion in oral tongue squamous cell carcinoma: comparison with MRI
Usefulness of contrast-enhanced CT in the evaluation of depth of invasion in oral tongue squamous cell carcinoma: comparison with MRI
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DOI：
10.1007/s11282-020-00429-y
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发表时间：
2020-02-21
期刊：
影响因子：
2.2
通讯作者：
Goto, Tazuko K.
中科院分区：
文献类型：
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作者：
Baba, Akira;Ojiri, Hiroya;Goto, Tazuko K.
目的目前尚无通过影像学诊断评估口腔舌鳞癌浸润深度（DOI）的标准化方法。我们通过评估对比增强计算机断层扫描（CECT）病理DOI与CECT和磁共振成像（MRI） DOI的相关性，研究了对比增强计算机断层扫描（CECT）在估计口腔舌鳞状细胞癌病理DOI中的有用性。方法回顾性分析2009年至2018年接受原发性口腔舌鳞状细胞癌根治性手术的139例患者中的21例。21例可评估，CECT无牙伪影。测量CECT和MRI上的DOI，以及病理DOI。结果病理中位DOI为9 mm， CECT为10.9 mm， t2加权MRI为14.2 mm，增强t1加权MRI为13.1 mm。CECT和MRI上的DOI大于病理DOI （p = 0.003 ~ < 0.001）。病理DOI与CECT的绝对值差异小于病理DOI与MRI的绝对值差异（p = 0.01和0.003）。CECT和MRI上的DOI与病理性DOI相关（r = 0.74-0.66，均p < 0.001）。CECT上DOI与病理DOI的Spearman相关系数大于MRI上DOI与病理DOI的Spearman相关系数。结论：与MRI扫描确定的DOI相比，CECT扫描确定的DOI与病理DOI相关且更接近病理DOI。因此，CECT可用于口腔舌鳞癌患者的术前分期。
Objectives There is currently no standardized approach for assessing the depth of invasion (DOI) of oral tongue squamous cell carcinoma via diagnostic imaging. We investigated the usefulness of contrast-enhanced computed tomography (CECT) for estimating the pathological DOI of oral tongue squamous cell carcinoma by evaluating the correlation of pathological DOI with the DOIs on CECT and magnetic resonance imaging (MRI). Methods We retrospectively reviewed 21 of 139 patients who underwent radical surgery for primary oral tongue squamous cell carcinoma between 2009 and 2018. The 21 cases were evaluable, without dental artifacts on CECT. DOIs on CECT and MRI, and pathological DOI were measured. Results The median pathological DOI was 9 mm, that on CECT was 10.9 mm, that on T2-weighted MRI was 14.2 mm, and that on contrast-enhanced T1-weighted MRI was 13.1 mm. The DOIs on CECT and on MRI were larger than the pathological DOI (p = 0.003 to < 0.001). The absolute value of the difference between pathological DOI and DOI on CECT was smaller than that between pathological DOI and DOI on MRI (p = 0.01 and 0.003). DOIs on CECT and on MRI correlated with pathological DOI (r = 0.74-0.66, all p < 0.001). Spearman's correlation coefficient between DOI on CECT and pathological DOI was greater than that between DOI on MRI and pathological DOI. Conclusions Compared to the DOI determined on an MRI scan, the DOI determined on a CECT scan correlated with and better approximated pathological DOI. Therefore, CECT can be useful for preoperative staging of patients with oral tongue squamous cell carcinoma.