Direct Alkynylation of Indole and Pyrrole Heterocycles
Direct Alkynylation of Indole and Pyrrole Heterocycles
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DOI：
10.1002/anie.200905419
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Waser, Jerome
中科院分区：
文献类型：
--
作者：
Brand, Jonathan P.;Charpentier, Julie;Waser, Jerome
容易做到：苯并碘度索酮炔基高碘烷1和金催化剂的独特性质允许开发高产率、操作简单（室温、无干燥溶剂或惰性条件、市售催化剂）的反应，用于在具有宽范围官能团的大范围吲哚和吡咯杂环上引入甲硅烷基乙炔（参见方案）。
Easy does it: The unique properties of benziodoxolone alkynyl periodinane 1 and gold catalysts have allowed the development of a high yielding, operationally simple (room temperature, no dry solvents or inert conditions, commercially available catalyst) reaction for the introduction of silylacetylenes on a large range of indole and pyrrole heterocycles with a wide range of functional groups (see scheme).