Rheumatoid arthritis and B lymphocyte alloantigen HLA-DRw4.
Rheumatoid arthritis and B lymphocyte alloantigen HLA-DRw4.
复制标题
类风湿性关节炎和 B 淋巴细胞同种异体抗原 HLA-DRw4。
作者：
O. Scherak;J. Smolen;W. Mayr
对40例典型或确诊的类风湿性关节炎患者进行了7种HLA-DR同种抗原和37种HLA-A、B和C抗原检测，并分别与125例和450例健康对照进行了比较。与对照组（23%）相比，类风湿关节炎组（55%）的HLA-DRw 4显著增加（校正p = 10（-3））。临床、影像学或血清学疾病参数与HLA-DRw 4之间无显著相关性。HLA-B8的频率在患者组中增加;然而，校正的p值不显著。
Forty Caucasian patients with classical or definite rheumatoid arthritis were tested for 7 HLA-DR alloantigens and 37 HLA-A, B, and C antigens and compared with 125 and 450 healthy controls, respectively. HLA-DRw4 was significantly (corrected p = 10(-3) increased in rheumatoid arthritis (55%) compared with controls (23%). There was no significant correlation between clinical, radiological or serological disease parameters and HLA-DRw4. The frequency of HLA-B8 was increased in the patient group; however, the corrected p value was not significant.