Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.
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DOI：
10.1007/s00213-016-4319-5
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发表时间：
2016-07
影响因子：
3.4
通讯作者：
Cowen PJ
中科院分区：
文献类型：
--
作者：
Masaki C;Sharpley AL;Cooper CM;Godlewska BR;Singh N;Vasudevan SR;Harmer CJ;Churchill GC;Sharp T;Rogers RD;Cowen PJ
锂仍然是双相情感障碍最有效的治疗方法，对降低自杀行为也有重要作用，这一特性可能与其减少冲动，攻击行为的能力有关。抗氧化剂药物依布硒啉（ebselen）已被提议作为一种可能的锂模拟物，这是基于其在动物中抑制肌醇单磷酸酶（IMPase）的能力，这是一种与锂共享的作用。该研究的目的是确定依布硒啉治疗是否改变了情绪处理，并减少了冒险行为的措施。我们研究了20名健康受试者，他们在两个场合接受依布硒啉（3600 mg，24小时）或相同的安慰剂，采用双盲、随机、交叉设计。最后一剂依布硒啉/安慰剂给药后3小时，参与者完成剑桥赌博任务（CGT）和一项需要检测情绪面部表情的任务（面部情绪识别任务（FERT））。在CGT上，相对于安慰剂，依布硒啉减少了延迟厌恶，而在FERT上，它增加了对积极与消极面部表情的识别。该研究表明，在使用的剂量下，依布硒啉可以降低冲动性，并在情绪处理中产生积极的偏见。这些研究结果表明，依布硒啉可能用于以冲动行为和烦躁情绪为特征的疾病。本文的在线版本（doi：10.1007/s 00213 -016-4319-5）包含补充材料，可供授权用户使用。
Lithium remains the most effective treatment for bipolar disorder and also has important effects to lower suicidal behaviour, a property that may be linked to its ability to diminish impulsive, aggressive behaviour. The antioxidant drug, ebselen, has been proposed as a possible lithium-mimetic based on its ability in animals to inhibit inositol monophosphatase (IMPase), an action which it shares with lithium. The aim of the study was to determine whether treatment with ebselen altered emotional processing and diminished measures of risk-taking behaviour. We studied 20 healthy participants who were tested on two occasions receiving either ebselen (3600 mg over 24 h) or identical placebo in a double-blind, randomized, cross-over design. Three hours after the final dose of ebselen/placebo, participants completed the Cambridge Gambling Task (CGT) and a task that required the detection of emotional facial expressions (facial emotion recognition task (FERT)). On the CGT, relative to placebo, ebselen reduced delay aversion while on the FERT, it increased the recognition of positive vs negative facial expressions. The study suggests that at the dosage used, ebselen can decrease impulsivity and produce a positive bias in emotional processing. These findings have implications for the possible use of ebselen in the disorders characterized by impulsive behaviour and dysphoric mood. The online version of this article (doi:10.1007/s00213-016-4319-5) contains supplementary material, which is available to authorized users.