Photodynamic therapy with verteporfin for choroidal neovascularization of pathologic myopia in Japanese patients: Comparison with nontreated controls
Photodynamic therapy with verteporfin for choroidal neovascularization of pathologic myopia in Japanese patients: Comparison with nontreated controls
复制标题
DOI：
10.1016/j.ajo.2007.10.032
复制
发表时间：
2008-03-01
影响因子：
4.2
通讯作者：
Mochizuki, Manabu
中科院分区：
文献类型：
--
作者：
Hayashi, Kengo;Ohno-Matsui, Kyoko;Mochizuki, Manabu
目的：研究椎泊芬光动力治疗（PDT）对日本病理性近视患者中央凹下或中央凹旁脉络膜新生血管（CNV）的影响，并将PDT治疗患者的视力结果与年龄匹配和视力匹配的未治疗对照组进行比较。设计：前瞻性、开放标签、连续、干预性病例系列。方法：我们对42例连续接受PDT治疗的病理性近视（bbb6屈光度或眼轴长>26.5 mm）患者43只眼进行前瞻性随访。并将随访1年以上患者的视力情况与同龄患者进行比较。初始视力与未接受治疗的对照组相当。结果：平均随访15.0±7.0个月。随访期间患者平均接受1.40 +/- 0.73次治疗，30只眼（69.8%）只需要一次治疗。最佳矫正视力（BCVA）改善2条Snellen线以上7眼（16.3%），下降6眼（14.0%），保持稳定30眼（69.7%）。在3只近中央凹CNV的眼中，PDT后检及血管造影均未检出CNV。统计分析显示，接受PDT治疗的患者在PDT后1年的视力明显好于年龄，初始BCVA与未接受治疗的对照组相当。结论：这些结果表明PDT有利于维持日本近视CNV患者的视力。PDT后的视力结果优于疾病的自然病程，由未经治疗的对照组确定。对CNV周围的绒毛膜视网膜萎缩的影响应进行长期研究。
PURPOSE: To examine the effects of photodynamic therapy (PDT) with verteporfin on subfoveal or juxtafoveal choroidal neovascularization (CNV) secondary to pathologic myopia in Japanese patients and to compare the visual outcomes of PDT-treated patients with that of age-matched and visual acuity-matched untreated controls.DESIGN: Prospective, open-label, consecutive, interventional case series.METHODS: We prospectively followed up 43 eyes of 42 consecutive patients with pathologic myopia (>6 diopters or axial length >26.5 mm) who received PDT for myopic CNV. In addition, the visual outcomes of these patients who were followed up for more than one year were compared with those of age. and initial visual acuity-matched untreated controls.RESULTS: The average follow-up was 15.0 +/- 7.0 months. Patients received an average of 1.40 +/- 0.73 treatments during follow-up, and 30 eyes (69.8%) required only one treatment. The best-corrected visual acuity (BCVA) improved by more than two Snellen lines in seven eyes (16.3%), decreased in six eyes (14.0%), and remained stable in 30 eyes (69.7%). In three eyes with a juxtafoveal CNV, CNV could not be detected ophthalmoscopically or angiographically after PDT. Statistical analysis showed that the PDT-treated patients had significantly better visual acuity at one year after PDT than the age, and initial BCVA,matched untreated controls.CONCLUSIONS: These results indicate that PDT was beneficial for maintaining vision in Japanese patients with myopic CNV. The visual outcome after PDT was better than the natural course of the disease as determined from untreated controls. The effect on chorioretinal atrophy around CNV should be investigated with a long-term study.