Thiodiketopiperazines from the Marine-Derived Fungus Phoma sp OUCMDZ-1847
Thiodiketopiperazines from the Marine-Derived Fungus Phoma sp OUCMDZ-1847
复制标题
来自海洋源性真菌点霉的硫代二酮哌嗪 OUCMDZ-1847
DOI：
10.1021/np400802d
复制
发表时间：
2014-01-01
影响因子：
5.1
通讯作者：
Zhu, Weiming
中科院分区：
文献类型：
--
作者：
Kong, Fandong;Wang, Yi;Zhu, Weiming
三种新的硫代二酮哌嗪，命名为phomazines A-C(1-3)，以及10种已知的类似物（4-13），从与红树植物Kandelia canddel相关的内生真菌Phoma sp. OUCMDZ-1847的发酵液中分离出来。通过光谱学、x射线晶体学和Mosher方法以及量子ECD和C-13核磁共振计算，明确地阐明了新化合物的结构，包括绝对构型。化合物2、4、5、11和12对HL-60、HCT-116、K562、MGC-803和A549细胞系具有细胞毒性，IC50值在0.05 ~ 8.5 μ M范围内。
Three new thiodiketopiperazines, named phomazines A-C (1-3), along with 10 known analogues (4-13), were isolated from the fermentation broth of an endophytic fungus, Phoma sp. OUCMDZ-1847, associated with the mangrove plant Kandelia candel. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic, X-ray crystallographic, and Mosher's methods along with quantum ECD and C-13 NMR calculations. Compounds 2, 4, 5, 11, and 12 showed cytotoxicities against the HL-60, HCT-116, K562, MGC-803, and A549 cell lines with IC50 values in the range 0.05 to 8.5 mu M.