Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome.
Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome.
复制标题
F1 雌性在与小鼠 DDK 综合征中的 Om 相关的 11 号染色体位点上的传输比畸变。
DOI：
10.1093/genetics/142.4.1299
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发表时间：
1996
期刊：
影响因子：
3.3
通讯作者：
Sapienza,C
中科院分区：
文献类型：
--
作者：
Pardo-ManualdeVillena,F;Slamka,C;Fonseca,M;Naumova,AK;Paquette,J;Pannunzio,P;Smith,M;Verner,A;Morgan,K;Sapienza,C
我们确定了超过200个雌性正反交F1杂交后代的基因型（在DDK和C57 BL/6 J近交系小鼠品系之间）和C57 BL/6 J雄性在与染色体11上的Ovum突变（Om）基因座连锁的标记处。与我们先前解释“DDK综合征”的遗传模型的期望相反，“这些后代的基因型并不反映在Omlocus定位的11号染色体区域从F1代雌性获得C57 BL/6 J等位基因的个体的优先存活。事实上，我们观察到显着的传输比失真，有利于DDK等位基因在这一地区。这些结果也与Wakasugi对Om遗传的遗传模型的预期相反，他在该模型中提出了DDK和非DDK等位基因从F1雌性中的平等传递。我们认为，这些实验的结果可能是由于母本DDKOme等位基因表达减少，或者母本DDKOme等位基因仅在F1代雌性的部分卵中表达
We determined the genotypes of >200 offspring that are survivors of matings between female reciprocal F1hybrids (between the DDK and C57BL/6J inbred mouse strains) and C57BL/6J males at markers linked to theOvum mutant (Om)locus on chromosome11.In contrast to the expectations of our previous genetic model to explain the “DDK syndrome,” the genotypes of these offspring do not reflect preferential survival of individuals that receive C57BL/6J alleles from the F1females in the region of chromosome11to which theOmlocus has been mapped. In fact, we observe significant transmission-ratio distortion in favor of DDK alleles in this region. These results are also in contrast to the expectations of Wakasugi's genetic model for the inheritance ofOm, in which he proposed equal transmission of DDK and non-DDK alleles from F1females. We propose that the results of these experiments may be explained by reduced expression of the maternal DDKOmallele or expression of the maternal DDKOmallele in only a portion of the ova of F1females