cncRNAdb: a manually curated resource of experimentally supported RNAs with both protein-coding and noncoding function.
cncRNAdb: a manually curated resource of experimentally supported RNAs with both protein-coding and noncoding function.
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cncRNAdb：手动管理的实验支持的 RNA 资源，具有蛋白质编码和非编码功能。
DOI：
10.1093/nar/gkaa791
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发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Huang Y;Wang J;Zhao Y;Wang H;Liu T;Li Y;Cui T;Li W;Feng Y;Luo J;Gong J;Ning L;Zhang Y;Wang D;Zhang Y
同时具有蛋白质编码和非编码功能的RNA被称为双功能RNA、双功能RNA或cncRNA(编码和非编码RNA)。最近，越来越多的cncRNAs被发现，包括翻译的ncRNAs(具有编码功能的ncRNAs)和非翻译的mRNAs(具有非编码功能的mRNAs)。然而，仍然缺乏一个适当的数据库来存储和组织cncRNA。在这里，我们开发了cncRNAdb，一个手动管理的实验支持的cncRNAs数据库，旨在为cncRNAs的有效操作、浏览和分析提供资源。当前版本的cncRNAdb记录了约2600个人工挑选的cncRNA功能条目，并提供了实验证据，涉及20多个物种的2000多个RNA(包括1300多个已翻译的ncRNA和600多个未翻译的mRNAs)。总之，我们相信cncRNAdb将有助于阐明cncRNAs的功能和机制，并开发新的预测方法。该数据库可在http://www.rna-society.org/cncrnadb/.上获得
RNA endowed with both protein-coding and noncoding functions is referred to as ‘dual-function RNA’, ‘binary functional RNA (bifunctional RNA)’ or ‘cncRNA (coding and noncoding RNA)’. Recently, an increasing number of cncRNAs have been identified, including both translated ncRNAs (ncRNAs with coding functions) and untranslated mRNAs (mRNAs with noncoding functions). However, an appropriate database for storing and organizing cncRNAs is still lacking. Here, we developed cncRNAdb, a manually curated database of experimentally supported cncRNAs, which aims to provide a resource for efficient manipulation, browsing and analysis of cncRNAs. The current version of cncRNAdb documents about 2600 manually curated entries of cncRNA functions with experimental evidence, involving more than 2,000 RNAs (including over 1300 translated ncRNAs and over 600 untranslated mRNAs) across over 20 species. In summary, we believe that cncRNAdb will help elucidate the functions and mechanisms of cncRNAs and develop new prediction methods. The database is available at http://www.rna-society.org/cncrnadb/.
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