Global cardiac remodeling after acute myocardial infarction: a study in the rat model.
Global cardiac remodeling after acute myocardial infarction: a study in the rat model.
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DOI：
10.1016/s0735-1097(85)80348-x
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发表时间：
1985-06
影响因子：
24
通讯作者：
H. Weisman;D. Bush;J. Mannisi;B. H. Bulkley
中科院分区：
文献类型：
--
作者：
H. Weisman;D. Bush;J. Mannisi;B. H. Bulkley
梗塞扩大，即梗塞区的局部扩张和变薄，发生在心肌梗塞后1天内。梗塞扩张区域形状的早期变化是否影响远端正常区域的结构尚不清楚。为了研究这个问题，45只患有透壁性梗塞的大鼠在梗塞后1、2和3天被处死，并检查它们的心脏的梗塞大小和扩张程度。在梗塞区域内、邻近区域和远离梗塞区域的地方测量壁厚和曲率半径。对八个对照心脏中的等效区域进行了分析。扩张的心脏梗塞区内壁不成比例变薄和曲率半径增加的程度不依赖于梗塞大小。在心脏扩张的邻近和远端区域也观察到明显的壁变薄和区域曲率半径增加（p < 0.001）。梗塞之外的这些结构变化的发生与梗塞年龄和大小无关，并且在没有梗塞扩张的心脏中未观察到。因此，当梗塞区域发生不成比例的变薄和扩张时，会伴随着包括远端正常心肌在内的整个心脏的形状变形。非梗塞心肌的这种远程重塑与扩张程度相关，但与梗塞的年龄或大小无关。
Infarct expansion, regional dilation and thinning of the infarct zone, occurs within 1 day after myocardial infarction. Whether the early change in regional shape of infarct expansion affects the architecture of remote normal regions is unknown. To study this question, 45 rats with a transmural infarct were killed at 1, 2 and 3 days after infarction and their hearts were examined for infarct size and extent of expansion. Wall thickness and radius of curvature were measured within, adjacent to and remote from the infarct zone. Equivalent regions were analyzed in eight control hearts.The extent of disproportionate wall thinning and increased radius of curvature within the infarct zone of hearts with expansion was not dependent on infarct size. Significant wall thinning and increased regional radius of curvature were also seen in adjacent and remote regions of the hearts with expansion (p < 0.001). These structural changes outside of the infarct occurred independent of infarct age and size, and were not seen in hearts without infarct expansion. Thus, when disproportionate thinning and dilation occur in the infarct region, they are accompanied by a distortion in shape of the entire heart including remote normal myocardium. This remote remodeling of noninfarcted myocardium correlates with extent of expansion, but not with age or size of the infarct.