The hygiene hypothesis revisited
The hygiene hypothesis revisited
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DOI：
10.1016/j.iac.2005.03.005
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发表时间：
2005-05-01
影响因子：
2.6
通讯作者：
Gem, JE
中科院分区：
文献类型：
--
作者：
Bufford, JD;Gem, JE
最初的卫生假说认为，家庭规模的缩小和儿童感染的暴露是特应性疾病增加的原因。已经进行了许多流行病学和纵向研究来验证这一假设，这一假设是根据这些发现和与先天免疫应答和免疫调节机制相关的新兴概念而演变的。总的来说，这些进展带来了希望，即最初卫生假说中所支持的概念可能很快会导致特应性疾病的新预防方法。
The original hygiene hypothesis proposed that reductions in family size and exposure to childhood infections were responsible for the rise in atopic diseases. Numerous epidemiologic and longitudinal studies have been performed to test this hypothesis, which has evolved in response to these findings and emerging concepts related to the innate immune response and immunoregulatory mechanisms. Collectively, these advances raise hope that the concepts espoused in the original hygiene hypothesis may soon lead to new preventive approaches to atopic diseases.