Enteral feeding of premature infants with Saccharomyces boulardii
Enteral feeding of premature infants with Saccharomyces boulardii
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DOI：
10.1016/s0378-3782(03)00090-2
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发表时间：
2003-11-01
影响因子：
2.5
通讯作者：
Petroehilou, V
中科院分区：
文献类型：
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作者：
Costalos, C;Skouteri, V;Petroehilou, V
背景：布拉酵母菌 (SB) 是一种既充当益生菌又充当多胺生产者的酵母。益生菌可防止肠道内病原体过度生长，而多胺则可促进肠道成熟。这项随机研究的目的是调查 SB 改变肠道微生物生态及其功能的能力。方法：对 87 名胎龄 28-32 周的健康婴儿进行了研究。他们被随机分配接受添加 SB 或麦芽糖糊精的早产儿配方奶粉，为期 30 天。对以下项目进行评价：SB耐受性和体重增加、粪便菌群分析、肠道D-木糖吸收和粪便脂质排泄。结果：婴儿对 SB 的耐受性良好。两组之间的体重增加没有差异。 SB 组中每克粪便中大肠杆菌和肠球菌菌落形成单位的中值对数显着较低 [E.大肠杆菌：2.67 (0.045) 与 2.75 (0.058)，P
Background: Saccharomyces boulardii (SB) is a yeast that acts both as a probiotic and as a polyamine producer. Probiotics prevent the overgrowth of pathogens in the gut while polyamines enhance intestinal maturation. The aim of this randomized study was to investigate the ability of SB to modify the gut microbial ecology and its function. Methods: A total of 87 healthy babies with gestational age 28-32 weeks were studied. They were randomly assigned to receive a preterm formula to which SB or maltodextrins was added for 30 days. Evaluations were made on the following: SB tolerance and weight gain, faecal flora analysis, intestinal D-Xylose absorption and faecal lipid excretion. Results: SB was well tolerated by the infants. There was no difference in weight gain between the two groups. Median log of colony forming units per gram of faeces for Escherichia coli and enterococci was significantly lower in the SB group [E. coli: 2.67 (0.045) vs. 2.75 (0.058), P