Monosomy 7 predisposes to diabetes insipidus in leukaemia and myelodysplastic syndrome
Monosomy 7 predisposes to diabetes insipidus in leukaemia and myelodysplastic syndrome
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7号单体易患白血病和骨髓增生异常综合征中的尿崩症
DOI：
10.1111/j.1600-0609.1987.tb01447.x
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发表时间：
1987
影响因子：
3.1
通讯作者：
R. Lahtinen
中科院分区：
文献类型：
--
作者：
A. Chapelle;R. Lahtinen
我们研究了4名同时患有尿崩症（DI）和急性非淋巴细胞白血病的患者的骨髓中的染色体。临床结果表明，在每一个病例中，骨髓增生异常综合征都先于急性白血病发作。文献中描述的另外两名此类患者进行了骨髓细胞带型核型研究。所有6例患者均存在7号染色体缺失。3例为7号单体染色体异常，2例为7号单体染色体异常伴其他克隆性异常，1例为del（7）（q22）染色体异常伴其他克隆性异常。这些数据表明7号单体或7q22-qter的单体易患DI。产生拟议倾向的机制尚待澄清。
We studied the chromosomes in the bone marrow of 4 patients who had both diabetes insipidus (DI) and acute non‐lymphocytic leukaemia. Clinical findings suggested that, in each case, myelodysplastic syndrome had preceded the onset of acute leukaemia. Two other such patients described in the literature had had a banded karyotype study of bone marrow cells. All 6 patients had deletions of chromosome 7. 3 had monosomy 7 as the sole cytogenetic abnormality, 2 had monosomy 7 associated with other clonal abnormalities and 1 had del(7)(q22) in association with other abnormalities. These data suggest that monosomy 7 or perhaps monosomy for 7q22‐qter predisposes to DI. The mechanism by which the proposed predisposition is produced remains to be clarified.