Contactless diamagnetic trapping of living cells onto a micromagnet array
Contactless diamagnetic trapping of living cells onto a micromagnet array
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非接触式反磁性将活细胞捕获到微磁体阵列上
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
G. Reyne
中科院分区：
文献类型：
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作者：
M. Frénéa;H. Chetouani;N. Haddour;H. Rostaing;J. Laforêt;G. Reyne
本文着重于将磁电泳应用于一种新的细胞图案化方法。该原理通过使用CoPt微磁体阵列来证明，该阵列产生规则间隔的磁阱，其中细胞在负磁电泳的作用下被限制而没有任何接触。为了获得这种效果，将抗磁性的酵母细胞（酿酒酵母）置于富含顺磁性离子的水溶液中。通过磁电泳进行的未标记（非磁性）细胞操作需要产生高磁场梯度，以确保显著的力。因此，微磁体对我们的应用特别感兴趣，因为磁场梯度随着磁体尺寸的减小而增加。
this paper focuses on the application of magnetophoresis to a new cell patterning method. The principle was demonstrated by using a CoPt micromagnet array, producing regularly spaced magnetic traps where cells were confined without any contact under the effect of negative magnetophoresis. To obtain this effect, yeast cells (Saccharomyces cerevisiae), which are diamagnetic, were placed in an aqueous solution enriched in paramagnetic ions. Unlabeled (non-magnetic) cell manipulation by magnetophoresis requires the production of high magnetic field gradients, ensuring significant forces. Therefore, micromagnets are particularly interesting for our application, since the field gradient increases as magnet dimensions are reduced.