From premature birth to premature kidney disease: does accelerated aging play a role?
From premature birth to premature kidney disease: does accelerated aging play a role?
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DOI：
10.1007/s00467-023-06208-1
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发表时间：
2023-11
影响因子：
3
通讯作者：
Keia R Sanderson;Christel Wekon-Kemeni;Jennifer R Charlton
中科院分区：
文献类型：
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作者：
Keia R Sanderson;Christel Wekon-Kemeni;Jennifer R Charlton
过去 30 年来，随着胎儿生存能力的限制不断增加，越来越多的证据支持这样的观点：除了早产后的生存之外，还应该更多地考虑慢性疾病。越来越多的证据还表明，早产后生物衰老会提前发生。同样，慢性肾脏病（CKD）也与超过实际年龄的高生物学年龄表型相关。然而，对于早产后过早的生物学年龄与肾脏疾病之间的联系，仍然存在重大的知识差距。这篇综述总结了衰老的四大支柱、早产后过早衰老的证据以及慢性肾病的情况。目的是提供额外的合理的生物学机制来探索早产和 CKD 之间的联系。需要更多的研究来进一步阐明早衰范式和早产后肾脏疾病的生物学机制。鉴于有关过早衰老疗法的新兴研究，这种范例可以为预防晚期 CKD 创造途径。
As the limits of fetal viability have increased over the past 30 years, there has been a growing body of evidence supporting the idea that chronic disease should be taken into greater consideration in addition to survival after preterm birth. Accumulating evidence also suggests there is early onset of biologic aging after preterm birth. Similarly, chronic kidney disease (CKD) is also associated with a phenotype of advanced biologic age which exceeds chronologic age. Yet, significant knowledge gaps remain regarding the link between premature biologic age after preterm birth and kidney disease. This review summarizes the four broad pillars of aging, the evidence of premature aging following preterm birth, and in the setting of CKD. The aim is to provide additional plausible biologic mechanisms to explore the link between preterm birth and CKD. There is a need for more research to further elucidate the biologic mechanisms of the premature aging paradigm and kidney disease after preterm birth. Given the emerging research on therapies for premature aging, this paradigm could create pathways for prevention of advanced CKD.