Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma
Presence of human papillomavirus DNA in plucked eyebrow hairs is associated with a history of cutaneous squamous cell carcinoma
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DOI：
10.1046/j.1523-1747.2003.12632.x
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发表时间：
2003-12-01
影响因子：
6.5
通讯作者：
Feltkamp, MCW
中科院分区：
文献类型：
--
作者：
Struijk, L;Bavinck, JNB;Feltkamp, MCW
皮肤人乳头瘤病毒（HPV）在皮肤癌的发展中的作用已经提出。设计良好的流行病学研究，以证明HPV感染和皮肤癌之间的关联是非常罕见的。为了确定HPV感染是一个潜在的危险因素，我们调查了眉毛中HPV DNA的存在与皮肤鳞状细胞癌病史之间的关系。设计了一项病例对照研究，包括155名有鳞状细胞癌病史的免疫功能正常的个体和371名无皮肤癌的对照。采用皮肤HPV亚群聚合酶链反应和新设计的HPV 2、5、8、15、16、20、24和38型HPV类型特异性聚合酶链反应，对从研究人群中采集的拔出的眉毛中提取的DNA进行分析。HPV DNA检出率为63.1%。HPV DNA的存在与年龄（p=0.0002）和男性（p=0.02）有关，但与阳光照射、皮肤类型和吸烟无关。校正年龄和性别后，眉毛中HPV DNA的存在与鳞状细胞癌病史相关（比值比1.7，95%置信区间1.1; 2.7）。HPV类型特异性分析显示，没有HPV类型脱颖而出。高危粘膜型HPV 16和皮肤疣型HPV 2在本研究中少见（
A role for cutaneous human papillomaviruses (HPV) has been proposed in the development of skin cancer. Well-designed epidemiologic studies to demonstrate an association between HPV infection and skin cancer are extremely rare. To identify HPV infection as a potential risk factor, we investigated the association between the presence of HPV DNA in eyebrow hairs and a history of cutaneous squamous cell carcinoma. A case-control study was designed consisting of 155 immunocompetent individuals with a history of squamous cell carcinoma and 371 controls without skin cancer. DNA extracted from plucked eyebrow hairs collected from the study population was analyzed with a cutaneous HPV subgroup polymerase chain reaction and newly designed HPV type specific polymerase chain reactions for HPV 2, 5, 8, 15, 16, 20, 24, and 38. HPV DNA was detected in 63.1% of the total study population. The presence of HPV DNA was associated with age (p=0.0002) and male sex (p=0.02), but not with sun exposure, skin type, and smoking. After adjustment for age and sex, the presence of HPV DNA in eyebrow hairs was associated with a history of squamous cell carcinoma (odds ratio 1.7, 95% confidence interval 1.1; 2.7). HPV type specific analysis revealed that no HPV type stood out. The high-risk mucosal type HPV 16 and the skin wart type HPV 2 were rarely found in this study (