Non-coding RNAs and disease: the classical ncRNAs make a comeback.
Non-coding RNAs and disease: the classical ncRNAs make a comeback.
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DOI：
10.1042/bst20160089
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发表时间：
2016-08-15
影响因子：
3.9
通讯作者：
O'Keefe RT
中科院分区：
文献类型：
--
作者：
de Almeida RA;Fraczek MG;Parker S;Delneri D;O'Keefe RT
许多人类疾病都归因于人类基因组蛋白质编码区域的突变。然而，与基因组的非编码部分相比，人类基因组的蛋白质编码部分非常小。因此，与基因组的非编码部分相比，有不成比例的疾病归因于编码部分。现在很清楚，基因组的非编码部分产生许多功能性的非编码rna，这些rna正在慢慢地与人类疾病联系起来。在这里，我们讨论了经典非编码rna突变被归因于人类疾病的例子，并确定了基因组非编码部分在疾病生物学中的未来潜力。
Many human diseases have been attributed to mutation in the protein coding regions of the human genome. The protein coding portion of the human genome, however, is very small compared to the non-coding portion of the genome. As such, there are a disproportionate number of diseases attributed to the coding compared to the non-coding portion of the genome. It is now clear that the non-coding portion of the genome produces many functional non-coding RNAs and these RNAs are slowly being linked to human diseases. Here we discuss examples where mutation in classical non-coding RNAs have been attributed to human disease and identify the future potential for the non-coding portion of the genome in disease biology.