Serum vitamin K level and bone mineral density in post-menopausal women
Serum vitamin K level and bone mineral density in post-menopausal women
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DOI：
10.1016/s0020-7292(96)02790-7
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发表时间：
1997-01-01
影响因子：
3.8
通讯作者：
Saji, F
中科院分区：
文献类型：
--
作者：
Kanai, T;Takagi, T;Saji, F
目的：维生素K通过促进骨钙素（BGP）的合成而影响骨代谢。绝经后骨密度急剧下降。我们调查了绝经后妇女骨密度、维生素K水平和其他骨代谢生物学参数之间的关系。研究方法：本文测定了71例绝经后妇女（19例骨密度降低，52例骨密度正常）和24例接受激素替代治疗（HRT）的更年期妇女（6例骨密度降低，18例骨密度正常）的血清维生素K、骨钙素（BGP）和其他骨代谢指标。结果如下：在第一组中，骨矿物质密度降低的妇女的维生素K1和K2水平低于骨矿物质密度正常的妇女。另一组在HRT期间BGP水平下降，但维生素K水平没有增加。结论：维生素K与绝经后骨丢失有关。(C)1997年国际妇产科联合会。
Objective: Vitamin K is known to influence bone metabolism by facilitating the synthesis of osteocalcin (BGP). The bone mineral density decreases drastically after menopause. We investigated the relationship of bone mineral density, vitamin K levels and other biological parameters of bone metabolism in post-menopausal women. Methods: Serum levels of vitamin K, BGP and other markers of bone metabolism were measured in 71 post-menopausal women (19 with reduced bone mineral density and 52 with normal bone density), and 24 women with climacteric symptoms receiving hormone replacement therapy (HRT), (6 with reduced bone mineral density and 18 with normal density). Results: In the first group, women with reduced bone mineral density showed lower levels of vitamin K1 and K2 than those with normal bone mineral density. In the other group, the level of BGP decreased but levels of vitamin K showed no increase during HRT. Conclusion: The present findings suggested that vitamin K was related to post-menopausal bone mineral loss. (C) 1997 International Federation of Gynecology and Obstetrics.