Choline Molecular Imaging with Small-animal PET for Monitoring Tumor Cellular Response to Photodynamic Therapy of Cancer.
Choline Molecular Imaging with Small-animal PET for Monitoring Tumor Cellular Response to Photodynamic Therapy of Cancer.
复制标题
使用小动物 PET 进行胆碱分子成像，用于监测肿瘤细胞对癌症光动力疗法的反应。
DOI：
10.1117/12.812129
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Schluchter,Mark
中科院分区：
文献类型：
--
作者：
Fei,Baowei;Wang,Hesheng;Wu,Chunying;Meyers,Joseph;Xue,Liang-Yan;Maclennan,Gregory;Schluchter,Mark
We are developing and evaluating choline molecular imaging with positron emission tomography (PET) for monitoring tumor response to photodynamic therapy (PDT) in animal models. Human prostate cancer (PC-3) was studied in athymic nude mice. A second-generation photosensitizer Pc 4 was used for PDT in tumor-bearing mice. MicroPET images with 11C-choline were acquired before PDT and 48 h after PDT. Time-activity curves of 11C-choline uptake were analyzed before and after PDT. For treated tumors, normalized choline uptake decreased significantly 48 h after PDT, compared to the same tumors pre-PDT (p < 0.001). However, for the control tumors, normalized choline uptake increased significantly (p < 0.001). PET imaging with 11C-choline is sensitive to detect early tumor response to PDT in the animal model of human prostate cancer.
