The mechanisms of chromogranin B-regulated Cl- homeostasis.
The mechanisms of chromogranin B-regulated Cl- homeostasis.
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DOI：
10.1042/bst20220435
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发表时间：
2022-12-16
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
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作者：
氯离子是几乎所有细胞和人体循环系统中最丰富的无机阴离子。因此，其稳态对于系统生理学和正常细胞活动是重要的。这一主题已被广泛研究的氯化物加载器和挤出器表达在细胞表面和细胞内膜。随着新发现的，大电导，高选择性Cl−通道形成的膜结合嗜铬粒蛋白B（CHGB），这不同于所有其他已知的阴离子通道的传统跨膜拓扑结构，并分布在质膜，内膜系统，内体，和内溶酶体区室表达它的细胞，我们将讨论的潜在生理重要性CHGB通道Cl−稳态，细胞兴奋性和体积控制，以及细胞和亚细胞水平上的阳离子摄取或释放。这些考虑和CHGB与人类疾病的关联使得CHGB通道成为未来分子治疗的可能药物靶标。
Chloride is the most abundant inorganic anions in almost all cells and in human circulation systems. Its homeostasis is therefore important for systems physiology and normal cellular activities. This topic has been extensively studied with chloride loaders and extruders expressed in both cell surfaces and intracellular membranes. With the newly discovered, large-conductance, highly selective Cl− channel formed by membrane-bound chromogranin B (CHGB), which differs from all other known anion channels of conventional transmembrane topology, and is distributed in plasma membranes, endomembrane systems, endosomal, and endolysosomal compartments in cells expressing it, we will discuss the potential physiological importance of the CHGB channels to Cl− homeostasis, cellular excitability and volume control, and cation uptake or release at the cellular and subcellular levels. These considerations and CHGB's association with human diseases make the CHGB channel a possible druggable target for future molecular therapeutics.
DOI：
10.1085/jgp.200609581
发表时间：
2006-09
期刊：
The Journal of general physiology
影响因子：
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作者：
Chien LT;Zhang ZR;Hartzell HC
通讯作者：
Hartzell HC
影响因子：
5.9
作者：
通讯作者：
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