AROMATASE ENZYME-ACTIVITY AND SEX DETERMINATION IN CHICKENS
AROMATASE ENZYME-ACTIVITY AND SEX DETERMINATION IN CHICKENS
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DOI：
10.1126/science.1734525
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发表时间：
1992-01-24
期刊：
影响因子：
56.9
通讯作者：
SMITH, RG
中科院分区：
文献类型：
--
作者：
ELBRECHT, A;SMITH, RG
在发育过程中，受精卵的基因型决定了性腺的性质，性腺的性质决定了雄性或雌性的表型。这一过程背后的分子事件才刚刚开始被定义。在鸡的性腺是双电位的阶段，用芳香酶抑制剂（阻断从睾酮合成雌激素）对鸡胚胎进行一次处理，导致遗传雌性发育为永久性雄性表型。这些性别逆转的雌性发育了双侧睾丸，能够完全发生精子，并具有正常雄性的身体外观和行为。这一结果确定了芳香化酶是鸡性别决定的关键发育开关。
During development, the genotype of the zygote determines the nature of the gonad, which then determines the male or female phenotype. The molecular events underlying this process are just beginning to be defined. A single treatment of chicken embryos with an aromatase inhibitor (which blocks the synthesis of estrogen from testosterone) at a stage when their gonads were bipotential caused genetic females to develop a permanent male phenotype. These sex-reversed females developed bilateral testes that were capable of complete spermatogenesis and had the physical appearance and behavior of normal males. This result identifies aromatase as a key developmental switch in the sex determination of chickens.