The expression of surface IgD on B cells responsive to thymus-independent and thymus-dependent antigens and its requirement for B-cell triggering.
The expression of surface IgD on B cells responsive to thymus-independent and thymus-dependent antigens and its requirement for B-cell triggering.
复制标题
B 细胞上表面 IgD 的表达对胸腺非依赖性和胸腺依赖性抗原有反应，及其对 B 细胞触发的要求。
作者：
S. Marshall‐clarke;K. Keeler;M. Parkhouse
基于细胞表面IgD（sIgD）表型，通过荧光激活细胞分选仪分离的细胞已被检查对胸腺依赖性和胸腺非依赖性抗原的反应性。还研究了单克隆抗IgD同种抗体在体外抑制对各种抗原的应答的能力。有证据表明，sIgD阳性和sIgD阴性细胞可以响应所有类型的抗原测试。然而，虽然sIgD的存在是必要的sIgD阳性细胞的胸腺依赖性抗原的反应，这种同种型的存在是不是强制性的sIgD阳性群体的胸腺非依赖性抗原的反应。根据这些发现，作为强制性的B细胞活化信号的供应商的可能作用的sIgD进行了讨论。
Cells separated by the fluorescence activated cell sorter on the basis of their surface IgD (sIgD) phenotype have been examined for responsiveness to thymus-dependent and thymus-independent antigens. The ability of monoclonal anti-IgD alloantibodies to inhibit responses in vitro to the various classes of antigen has also been investigated. Evidence is presented indicating that both sIgD positive and sIgD negative cells can respond to all types of antigen tested. However, although the presence of sIgD was necessary for the response of sIgD positive cells to thymus-dependent antigens, the presence of this isotype was not obligatory for the response of the sIgD positive population to thymus independent antigens. The possible role of sIgD as the obligatory purveyor of a B-cell activation signal is discussed in the light of these findings.