Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.
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DOI：
10.1097/mpa.0b013e318176b9ae
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发表时间：
2008-10
期刊：
影响因子：
2.9
通讯作者：
Von Hoff DD
中科院分区：
文献类型：
--
作者：
Warner SL;Muñoz RM;Bearss DJ;Grippo P;Han H;Von Hoff DD
To further explore the oncogenic activity of Aurora A kinase while attempting to develop a useful mouse model for pancreatic cancer, Aurora A kinase was targeted to Pdx-1 positive cells. Aurora A kinase overexpression was targeted to mouse pancreas tissue using the Pdx-1 promoter in a transgenic model. The pancreas tissue of 7–11 month old transgenic animals were evaluated for metastatic adenocarcinomas, preinvasive ductal neoplasia, or other histological anomalies. Examination of pancreatic tissue from Pdx-1-Aurora A transgenic mice revealed abnormalities, such as mild islet cell hyperplasia, lymphocytic infiltration, and general dysplasia between ductal/islet cell interfaces. However, the majority of the tissue from these transgenic mice was normal. The overexpression of Aurora A can potentially initiate the development of mild abnormalities in pancreatic tissue; however, neither preinvasive ductal neoplasia nor fully metastatic adenocarcinomas were observed. Combining the Pdx-1-Aurora A transgenic model with other genetic alterations may provide additional insight.
