Contribution of Sinerem(R) used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit
Contribution of Sinerem(R) used as blood-pool contrast agent: Detection of cerebral blood volume changes during apnea in the rabbit
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DOI：
10.1002/mrm.1910360313
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发表时间：
1996-09-01
影响因子：
3.3
通讯作者：
LeBihan, D
中科院分区：
文献类型：
--
作者：
Berry, I;Benderbous, S;LeBihan, D
作者认为，用作血池造影剂的超小顺磁性氧化铁（USPIO）颗粒可能会增加中场MRI的灵敏度（即，小于1.5特斯拉）与脑血容量的生理变化之间的关系。在增加pCO（2）和脑血容量的呼吸暂停家兔模型上对这一假设进行了测试。使用Sinerem（R）作为USPIO，在血液浓度为60 μ mol铁/kg体重时，在1.0 T下可以观察到8%T-2* 加权信号降低，pCO（2）增加25-33%。相比之下，在没有USPIO的情况下，由于脱氧血红蛋白含量增加，在呼吸暂停期间和轻度过度氧合后，T-2* 加权信号仅下降4%。这些初步数据表明，USPIO可以在中场强度的功能MRI中发挥重要作用，通过使信号对脑血容量变化敏感。
The authors suggest that ultra-small paramagnetic iron oxide (USPIO) particles used as blood pool contrast agents may increase the sensitivity of midfield MRI (i.e., less than 1.5 Tesla) to physiological variations in cerebral blood volume, This hypothesis was tested on a rabbit model of apnea which increases pCO(2) and cerebral blood volume, Using Sinerem(R) as the USPIO at a blood concentration of 60 mu mol iron/kg body weight, an 8% T-2*-weighted signal decrease could be observed at 1.0 T with 25-33% increase in pCO(2). Comparatively, in the absence of USPIO, T-2*-weighted signal dropped only 4% during apnea and after mild hyperoxygenation beforehand, due to increased deoxyhemoglobin content, These preliminary data suggest that USPIOs could play an important role in functional MRI at midfield strength, by sensitizing the signal to cerebral blood volume changes.