G1 phase regulation, area-specific cell cycle control, and cytoarchitectonics in the primate cortex
G1 phase regulation, area-specific cell cycle control, and cytoarchitectonics in the primate cortex
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DOI：
10.1016/j.neuron.2005.06.032
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发表时间：
2005-08-04
期刊：
影响因子：
16.2
通讯作者：
Dehay, C
中科院分区：
文献类型：
--
作者：
Lukaszewicz, A;Savatier, P;Dehay, C
我们已经研究了导致灵长类动物区17和18出现的细胞周期相关机制。这些区域的特点是细胞结构和神经元数量的显著差异。我们在体内发现(1)与18区前体相比，17区核上神经元的细胞周期持续时间更短，G1期减少，细胞周期再进入率更高；(2) 17区和18区前体细胞cyclin E（17区高，18区低）和p27(Kip1)（17区低，18区高）的表达水平存在差异和特异性；(3)体外对周期蛋白E和P27（Kip1）的上调和下调表明，这两种调节因子通过改变细胞周期进程和细胞周期再进入的速率来影响细胞周期动力学；(4)模拟细胞周期参数的区域差异表明，它们有助于前体数量和神经元产生的区域差异。
We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a reduced G1 phase, and a higher rate of cell cycle reentry than area 18 precursors; (2) area 17 and area 18 precursors show contrasting and specific levels of expression of cyclin E (high in area 17, low in area 18) and p27(Kip1) (low in area 17, high in area 18); (3) ex vivo up- and downmodulation of cyclin E and P27(Kip1) show that both regulators influence cell cycle kinetics by modifying rates of cell cycle progression and cell cycle reentry; (4) modeling the areal differences in cell cycle parameters suggests that they contribute to areal differences in numbers of precursors and neuron production.