STEADY-STATE GAMMA-RADIOLYSIS OF DEGERATED AQUEOUS-SOLUTIONS OF THYMIDINE
STEADY-STATE GAMMA-RADIOLYSIS OF DEGERATED AQUEOUS-SOLUTIONS OF THYMIDINE
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DOI：
10.1080/09553008114550141
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发表时间：
1981-01-01
影响因子：
2.6
通讯作者：
BERGER, M
中科院分区：
文献类型：
--
作者：
CADET, J;BALLAND, A;BERGER, M
稳态γ。胸苷脱气水溶液的辐射分解产生了嘧啶和核苷衍生物的复杂混合物。在这些化合物中，有 22 种被分离出来，并通过质子 NMR 和质谱等光谱方法进行了表征。主要的5,6-饱和产物被鉴定为5,6-二氢胸苷的5R和5S非对映异构体及其5和/或6-碳上的单羟基化和二羟基化衍生物。测定了这些不同化合物的G值。通过使用特定的自由基清除剂，即乙醇、叔丁醇和硝酸钾，研究了水的辐射分解产生的主要活性物质的作用。
The steady-state .gamma. radiolysis of deaerated aqueous solutions of thymidine generated a complex mixture of pyrmidine and nucleoside derivatives. Of these compounds, 22 were isolated and characterized by spectroscopic methods including proton NMR and mass spectrometry. The major 5,6-saturated products were identified as the 5R and 5S diasteroisomers of 5,6-dihydrothymidine and their mono and dihydroxylated derivatives on the 5 and/or 6-carbons. The G values of these various compounds were determined. The roles of the primary reactive species derived from the radiolysis of water were studied by using specific radical scavengers, i.e., ethanol, t-butanol and potassium nitrate.