Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons
Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons
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DOI：
10.1016/s0896-6273(02)00635-9
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发表时间：
2002-03-14
期刊：
影响因子：
16.2
通讯作者：
Ginty, DD
中科院分区：
文献类型：
--
作者：
Cloutier, JF;Giger, RJ;Ginty, DD
从外周的v形鼻器官（VNO）到副嗅球（AOB）的肾小球的轴突寻路机制尚不清楚。Neuropilin-2是一种分泌信号素的受体，在V1R-和vv3r -表达，而不是v2r -表达的出生后的颏鼻神经元中表达。对npn-2突变小鼠犁鼻神经的分析揭示了在多个选择点的寻径缺陷。vomeronas鼻感觉轴突严重失血，其中一部分支配主嗅球（MOB）。当大多数表达v1r的神经元轴突到达AOB并在典型位置汇聚到不同的肾小球时，它们不再局限于正常的AOB前靶区。因此，Npn-2和候选信息素受体在促进副嗅觉系统感觉神经元的连接和模式方面发挥着独特而互补的作用。
The mechanisms that underlie axonal pathfinding of vomeronasal neurons from the vomeronasal organ (VNO) in the periphery to select glomeruli in the accessory olfactory bulb (AOB) are not well understood. Neuropilin-2, a receptor for secreted semaphorins, is expressed in V1R- and V3R-expressing, but not V2R-expressing, postnatal vomeronasal neurons. Analysis of the vomeronasal nerve in neuropilin-2 (npn-2) mutant mice reveals pathfinding defects at multiple choice points. Vomeronasal sensory axons are severely defasciculated and a subset innervates the main olfactory bulb (MOB). While most axons of V1R-expressing neurons reach the AOB and converge into distinct glomeruli in stereotypic locations, they are no longer restricted to their normal anterior AOB target zone. Thus, Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system.