Selective breeding for increased home cage physical activity in collaborative cross and Hsd:ICR mice.
Selective breeding for increased home cage physical activity in collaborative cross and Hsd:ICR mice.
复制标题
选择性育种以增加协作杂交小鼠和 Hsd:ICR 小鼠的家笼体力活动。
DOI：
10.1007/s10519-010-9425-2
复制
发表时间：
2011
影响因子：
2.6
通讯作者：
Rhodes,JustinS
中科院分区：
文献类型：
--
作者：
Zombeck,JonathanA;Deyoung,ErinK;Brzezinska,WeronikaJ;Rhodes,JustinS
增加车轮运行和开放领域行为的选择性育种实验已经确定了与小鼠自愿体力活动增加相关的遗传和神经生物学因素，但以前的研究没有直接选择增加在笼子里行走的距离。因此，应用家族内选择来增加饲养笼活动，如使用两个不同的起始群体G2：F1协作杂交（CC）和Hsd：ICR小鼠通过连续视频跟踪所测量的。通过中亲后代回归分析评价了在跑步轮上和在开阔场地上行驶距离的遗传相关性。在CC中观察到对选择的显著反应，但在Hsd：ICR中未观察到。轮运行是遗传的，在这两个群体，但没有显着的遗传相关性与家庭笼活动。开阔视野在两个群体中都是不可遗传的。我们的结论是，不同的基因和神经回路影响身体活动的家庭笼相比，车轮运行或开放领域。在CC小鼠中选择性饲养的家笼活动值得进一步探索。
Selective breeding experiments for increased wheel running and open field behavior have identified genetic and neurobiological factors associated with increased voluntary physical activity in mice, but no previous study has directly selected for increased distance traveled in the home cage. Therefore, within-family selection was applied to increase home cage activity as measured by continuous video tracking using two different starting populations, G2:F1 Collaborative Cross (CC) and Hsd:ICR mice. Genetic correlations with distance traveled on running wheels and in the open field were evaluated by mid-parent offspring regression. A significant response to selection was observed in CC but not Hsd:ICR. Wheel running was heritable in both populations but not significantly genetically correlated with home cage activity. Open field was not heritable in either population. We conclude that different genes and neural circuits influence physical activity in the home cage as compared to wheel running or open field. Selective breeding for home cage activity in CC mice warrants further exploration.