Artificial cell-cell communication as an emerging tool in synthetic biology applications.
Artificial cell-cell communication as an emerging tool in synthetic biology applications.
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DOI：
10.1186/s13036-015-0011-2
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发表时间：
2015
影响因子：
5.6
通讯作者：
Ostermann K
中科院分区：
文献类型：
--
作者：
Hennig S;Rödel G;Ostermann K
细胞间通讯是自然界中普遍存在的现象，从细菌群体感应和真菌信息素通讯到多细胞真核生物中的细胞串扰。这些通信模式提供了通过以特定方式修改单个小区的性能来控制整个社区的行为的可能性。合成生物学，即，在生物系统中实现人工功能是一种有前途的方法，可以设计基于特定功能化细胞的复杂的自主装置。随着由这样的系统执行的功能的日益复杂，电路串扰的风险和由许多外源基因的表达引起的代谢负担都在增加。因此，基于单一类型细胞的系统不再可行。合成生物学方法具有多个特定功能化细胞亚群，通过人工细胞-细胞通信系统连接，提供了一种有吸引力和强大的替代方案。在这里，我们回顾了最近的应用程序的合成细胞间通讯系统，特别关注真菌宿主的最新进展。
Cell-cell communication is a widespread phenomenon in nature, ranging from bacterial quorum sensing and fungal pheromone communication to cellular crosstalk in multicellular eukaryotes. These communication modes offer the possibility to control the behavior of an entire community by modifying the performance of individual cells in specific ways. Synthetic biology, i.e., the implementation of artificial functions within biological systems, is a promising approach towards the engineering of sophisticated, autonomous devices based on specifically functionalized cells. With the growing complexity of the functions performed by such systems, both the risk of circuit crosstalk and the metabolic burden resulting from the expression of numerous foreign genes are increasing. Therefore, systems based on a single type of cells are no longer feasible. Synthetic biology approaches with multiple subpopulations of specifically functionalized cells, wired by artificial cell-cell communication systems, provide an attractive and powerful alternative. Here we review recent applications of synthetic cell-cell communication systems with a specific focus on recent advances with fungal hosts.
影响因子：
5.6
作者：
Bayer TS;Hoff KG;Beisel CL;Lee JJ;Smolke CD
通讯作者：
Smolke CD