Effect of Anticoagulants and Inhibitors of Platelet Aggregation on Thrombotic Occlusion of Endarterectomized Cat Carotid Arteries
Effect of Anticoagulants and Inhibitors of Platelet Aggregation on Thrombotic Occlusion of Endarterectomized Cat Carotid Arteries
复制标题
抗凝剂和血小板聚集抑制剂对动脉内膜切除术猫颈动脉血栓性闭塞的影响
作者：
D. Piepgras;T. Sundt;P. Didisheim
在手术显微镜下在1 cm段上切除直径为1.8 - 2 mm的猫颈动脉内膜，并用9-0单丝尼龙缝线闭合动脉切口。由于动脉切开术闭合错误而导致管腔明显狭窄的血管从研究中排除。根据动物治疗方法将血管分为6组：对照组、阿司匹林组、香豆素组、香豆素加阿司匹林组、肝素治疗4小时以下组和肝素治疗4 - 8小时组。未处理组中所有接受简单动脉切开术和闭合术的血管均保持通畅。动脉内膜切除术后，只有肝素表现出明显的有益效果，100%的血管治疗超过4小时，30%的治疗不到4小时的血管保持通畅。这与其他动脉内膜切除血管中的0%通畅率形成对比。
Cat carotid arteries measuring 1.8 to 2 mm in diameter were endarterectomized under the operating microscope over a 1-cm segment and the arteriotomy was closed with a 9-0 monofilament nylon suture. Vessels exhibiting significant narrowing of the lumen due to faulty closure of the arteriotomy were excluded from the study. The vessels were divided into six groups according to the method of treatment of the animals: control, aspirin, Coumadin, Coumadin plus aspirin, heparin for less than four hours, and heparin for four to eight hours. All vessels in the untreated group subjected to simple arteriotomy and closure remained patent. Only heparin demonstrated an apparent beneficial effect after endarterectomy with 100% of the vessels treated more than four hours and 30% of those treated less than four hours remaining patent. This is contrasted to a 0% patency in other endarterectomized vessels.