The metabolic state of cancer stem cells-a valid target for cancer therapy?
The metabolic state of cancer stem cells-a valid target for cancer therapy?
复制标题
癌症干细胞的代谢状态——癌症治疗的有效靶点？
DOI：
10.1016/j.freeradbiomed.2014.10.732
复制
发表时间：
2015
影响因子：
7.4
通讯作者：
Pajonk,Frank
中科院分区：
文献类型：
--
作者：
Vlashi,Erina;Pajonk,Frank
20世纪20年代，奥托·瓦尔堡首先描述了肿瘤中的高葡萄糖摄取、有氧糖酵解和高乳酸产生。从那时起，高葡萄糖摄取已被用于癌症PET成像的开发。然而，尽管对癌症中葡萄糖代谢的分子基础有了深入的了解，但正常组织和恶性组织之间的这种根本差异尚未用于临床中的靶向癌症治疗。在这篇综述中，我们强调了最近文献中针对癌细胞代谢的尝试，并详细阐述了这些策略的挑战和争议，以及癌症中肿瘤细胞异质性的背景。
In the 1920s Otto Warburg first described high glucose uptake, aerobic glycolysis, and high lactate production in tumors. Since then high glucose uptake has been utilized in the development of PET imaging for cancer. However, despite a deepened understanding of the molecular underpinnings of glucose metabolism in cancer, this fundamental difference between normal and malignant tissue has yet to be employed in targeted cancer therapy in the clinic. In this review, we highlight attempts in the recent literature to target cancer cell metabolism and elaborate on the challenges and controversies of these strategies in general and in the context of tumor cell heterogeneity in cancer.