Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: A retrospective analysis
Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: A retrospective analysis
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DOI：
10.1089/jwh.2007.0423
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发表时间：
2008-03-01
影响因子：
3.5
通讯作者：
Childress, Anna Rose
中科院分区：
文献类型：
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作者：
Franklin, Teresa R.;Ehrman, Ronald;Childress, Anna Rose
背景和目的：吸烟对健康的有害后果对妇女来说更为严重，但具有讽刺意味的是，她们比男子更难戒烟。重要的目标是确定妇女复发的预测因素，并实施战略，以增加她们成功戒烟和保持禁欲的机会。临床医生和研究人员建议，如果最初的戒烟尝试与卵泡期（即，排卵前期）而不是黄体期（即，经前）。然而，没有实验数据支持这一说法。我们的目的是确定MC阶段是否影响吸烟状态的绝经前女性吸烟者参加戒烟treatmenttrial.Methods：数据从102寻求治疗的吸烟者参加了8周尼古丁替代疗法（NRT）加行为干预戒烟研究进行了回顾性研究。NRT开始于受试者尝试戒烟的当天（戒烟日期）。吸烟者按性别分组，女性按MC期分为卵泡期（FF，第1 - 14天，n = 16）和黄体期（LF，第15 - 30天，n = 21）两组。结果：在戒烟后第3天（第3天）和治疗后1周（第9周）检查吸烟状况。在第3天，52%的LF报告吸烟，而FF为19%（p <0.04），在第9周，71%的LF报告吸烟，而FF为31%（p <0.02）。在男性对照组（n = 65）中，25%在第3天吸烟，68%在第9周吸烟。在第9周的自我报告进行了验证，尿可替宁levels.Conclusions：这些数据支持的假设，更好的治疗效果，可以通过安排戒烟日期，以配合卵泡期的MC在女性吸烟者。
Background and Objective: The deleterious health consequences of smoking are even more severe for women, yet ironically, they have more difficulty quitting than men. Identifying relapse predictors for women and implementing strategies to increase their chances of successfully quitting and remaining abstinent are important goals. Clinicians and researchers suggest that women could achieve greater success in smoking cessation interventions if the initial quit attempt coincided with the follicular phase (i.e., preovulatory phase) of their menstrual cycle ( MC) rather than the luteal phase (i.e., premenstrual). However, no experimental data have been published to support this claim. Our objective was to determine whether MC phase affected smoking status in premenopausal female smokers participating in a smoking cessation treatment trial.Methods: Data from 102 treatment- seeking smokers who participated in an 8-week nicotine replacement therapy ( NRT) plus behavioral intervention smoking cessation study were examined retrospectively. NRT began the day subjects attempted to quit smoking ( quit date). For analyses, smokers were grouped according to sex, and women were subdivided by MC phase at quit date into follicular ( FF, days 1 - 14, n = 16) and luteal (LF, days 15 - 30, n = 21) groups.Results: Smoking status was examined on the third day after the quit date ( day 3) and at 1 week posttreatment ( week 9). On day 3, 52% of LFs reported smoking compared with 19% of FFs ( p < 0.04), and at week 9, 71% of LFs reported smoking compared with 31% of FFs ( p < 0.02). In a comparison group of men ( n = 65), 25% were smoking at day 3 and 68% at week 9. Self-report at week 9 was verified by urine cotinine levels.Conclusions: These data support the supposition that better treatment outcomes can be achieved by scheduling quit dates to coincide with the follicular phase of the MC in female smokers.