Lesions of the human amygdala impair enhanced perception of emotionally salient events
Lesions of the human amygdala impair enhanced perception of emotionally salient events
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DOI：
10.1038/35077083
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发表时间：
2001-05-17
期刊：
影响因子：
64.8
通讯作者：
Phelps, EA
中科院分区：
文献类型：
--
作者：
Anderson, AK;Phelps, EA
与快速有效地评估动机上重要的刺激的重要性相对应，人类可能被赋予了不同的能力（1，2），并保持专门的神经结构，以加强其检测。在这里，我们认为人类杏仁核（3，4）的一个关键功能是增强对具有情感意义的刺激的感知。在有限的注意条件下，正常的知觉意识，即注意力瞬脱（5，6），我们表明，健康的观察者表现出强大的利益相比，中性内容的刺激厌恶内容的言语刺激的感知。相比之下，双侧杏仁核受损的患者对这种令人厌恶的刺激事件没有增强的感知。对切除左侧或右侧杏仁核的患者的检查表明，对厌恶性词语的增强感知特别依赖于左侧杏仁核。所有的患者理解正常的情感意义的刺激事件，尽管缺乏证据增强知觉编码这些事件的患者左杏仁核病变。我们的研究结果揭示了情感对感知的影响的神经基础，表明类似的神经机制可能是回忆（7-9）和感知经验的情感调制的基础。
Commensurate with the importance of rapidly and efficiently evaluating motivationally significant stimuli, humans are probably endowed with distinct faculties(1,2) and maintain specialized neural structures to enhance their detection. Here we consider that a critical function of the human amygdala(3,4) is to enhance the perception of stimuli that have emotional significance. Under conditions of limited attention for normal perceptual awareness-that is, the attentional blink(5,6)-we show that healthy observers demonstrate robust benefits for the perception of verbal stimuli of aversive content compared with stimuli of neutral content. In contrast, a patient with bilateral amygdala damage has no enhanced perception for such aversive stimulus events. Examination of patients with either left or right amygdala resections shows that the enhanced perception of aversive words depends specifically on the left amygdala. All patients comprehend normally the affective meaning of the stimulus events, despite the lack of evidence for enhanced perceptual encoding of these events in patients with left amygdala lesions. Our results reveal a neural substrate for affective influences on perception, indicating that similar neural mechanisms may underlie the affective modulation of both recollective(7-9) and perceptual experience.