Human Chitotriosidase: a Sensitive Biomarker of Sarcoidosis
Human Chitotriosidase: a Sensitive Biomarker of Sarcoidosis
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DOI：
10.1007/s10875-012-9754-4
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发表时间：
2013-01-01
影响因子：
9.1
通讯作者：
Rottoli, Paola
中科院分区：
文献类型：
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作者：
Bargagli, Elena;Bennett, David;Rottoli, Paola
背景结节病是一种病因不明的多系统肉芽肿性疾病。目前还没有合适的生物标记物来评估这种疾病的演变，这种疾病的临床过程仍然不可预测。目的与方法本研究的目的和方法是在锡耶纳结节病区域转诊中心的观察下，对232例结节病患者进行检测，以评估其敏感性和特异性，并分析不同疾病表型的酶浓度(按最近发表的COS分类)以确定其预后价值。结果患者血清中的甲壳三糖苷酶浓度显著高于健康对照组(P
Background Sarcoidosis is a multisystem granulomatous disease of unknown etiology. No suitable biomarkers are available to evaluate the evolution of this disease, which still has an unpredictable clinical course. Some years ago our research group proposed chitotriosidase as a potential biomarker with prognostic value, that however needed to be validated.Aims and methods The aims of this study were to evaluate the sensitivity and specificity of chitotriosidase in a population of 232 sarcoidosis patients under the observation of our Sarcoidosis Regional Referral Centre in Siena and to analyse enzyme concentrations in different disease phenotypes (as defined by the recently published COS classification) to define its prognostic value.Results Serum chitotriosidase concentrations were significantly higher in patients than in healthy controls (p