The hippocampus: a special place for time
The hippocampus: a special place for time
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DOI：
10.1111/nyas.13043
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Hsieh, Liang-Tien
中科院分区：
文献类型：
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作者：
Ranganath, Charan;Hsieh, Liang-Tien
许多研究结果表明，对过去事件的记忆是按时间顺序组织的。众所周知，海马体对于此类情景记忆至关重要，但直到最近，人们对海马体助记表征的时间组织知之甚少。人类和动物研究的最新进展揭示了关于海马体在学习和检索事件序列中的作用的重要见解。在这里，我们回顾了这些发现，包括啮齿动物的病变和单单元记录研究、人类的功能磁共振成像研究，以及将这些研究结果与海马回路解剖结构联系起来的计算模型。研究结果一致认为，海马体对于学习事件序列至关重要，它使大脑能够区分概念上相似但时间上不同的事件的记忆，并将时间上连续但不相关的经历的表征联系起来。
Many findings have demonstrated that memories of past events are temporally organized. It is well known that the hippocampus is critical for such episodic memories, but, until recently, little was known about the temporal organization of mnemonic representations in the hippocampus. Recent developments in human and animal research have revealed important insights into the role of the hippocampus in learning and retrieving sequences of events. Here, we review these findings, including lesion and single-unit recording studies in rodents, functional magnetic resonance imaging studies in humans, and computational models that link findings from these studies to the anatomy of the hippocampal circuit. The findings converge toward the idea that the hippocampus is essential for learning sequences of events, allowing the brain to distinguish between memories for conceptually similar but temporally distinct episodes, and to associate representations of temporally contiguous, but otherwise unrelated experiences.