Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels
Diurnal variation of serum iron, iron-binding capacity, transferrin saturation, and ferritin levels
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DOI：
10.1309/2yt4-cmp3-kyw7-9rk1
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发表时间：
2002-05-01
影响因子：
3.5
通讯作者：
Zinsmeister, AR
中科院分区：
文献类型：
--
作者：
Dale, JC;Burritt, MF;Zinsmeister, AR
血清铁水平全天变化。通常认为早上的水平高于下午或晚上的水平。我们研究了是否有必要将血清铁的采集限制在早晨。对20名健康成人志愿者在第1天上午8时、中午12时、下午4时和第2天上午8时采集的077份血样进行血清铁、铁结合力、转铁蛋白饱和度和铁蛋白水平测定。虽然观察到铁、铁结合力和（log）铁蛋白的采集时间平均值之间存在统计学显著差异，但未观察到一致的昼夜变化。早上的铁含量高于下午的水平，只有一半的受试者。所有4种分析物的日间变异与日内变异相似。我们的结论是，限制铁标本采集到一天中的特定时间的做法并没有提高测试结果的可靠性。
Serum iron levels vary throughout the day. Morning levels are generally assumed to be higher than afternoon or evening levels. We studied whether our practice of restricting serum iron collections to the morning was necessary. Serum iron, iron-binding capacity, transferrin saturation, and ferritin levels were determined 077 blood specimens obtained from 20 healthy adult volunteers at 8 AM, noon, and 4 Pm (day 1) and 8 AM (day 2). Although statistically significant differences among mean values for the collection times were observed for iron, iron-binding capacity,, and (log) ferritin, no consistent diurnal variation was seen. Morning iron levels were higher than afternoon levels for only, half of the subjects. Between-day variation for all 4 analytes was similar to within-day variation. We conclude that the practice of restricting iron specimen collections to a specific time of day does not improve the reliability of the test result.