Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children
Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children
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儿童阿尔茨海默病的多基因风险评分和心脏代谢危险因素的轨迹
DOI：
10.1101/580548
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Korologou-Linden R
中科院分区：
文献类型：
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作者：
Korologou-Linden R
心脏代谢因子与阿尔茨海默病的病因学有关，可能存在于将遗传变异与阿尔茨海默病的整个生命过程联系起来的途径上。我们研究是否多基因风险评分（PRS）与心脏代谢健康指标，通过童年和adolescence.MethodsIn从雅芳纵向研究的父母和孩子的7,977名参与者，我们测试是否PRS阿尔茨海默病与心脏代谢危险因素的轨迹。我们检查了1-18岁时的身高轨迹; 9-18岁时的瘦体重和脂肪量; 7-18岁时的收缩压和舒张压; 9-18岁时的葡萄糖和C反应蛋白; 10-18岁时的胰岛素;以及18岁时的高密度和低密度脂蛋白和甘油三酯。我们还检查了9岁时的出生体重和白细胞介素-6（IL-6），以及11岁、12岁时的体力活动，ResultsNo consistent associations were observed between the PRS excluding genetic variants in the apolipoprotein E gene region and cardiometabolic factors trajectories across childhood and adolescents. Conclusions我们没有发现证据表明阿尔茨海默病的PRS作用贯穿儿童期，青少年心脏代谢危险因素。进一步的研究应该检查这些关联是否在成年后出现，那时心脏代谢危险因素的变化可能更大。
IntroductionCardiometabolic factors are implicated in the aetiology of Alzheimer’s disease and may lie on the pathways linking genetic variants to Alzheimer’s disease across the life course. We examined whether polygenic risk scores (PRS) were associated with cardiometabolic health indicators through childhood and adolescence.MethodsIn 7,977 participants from the Avon Longitudinal Study of Parents and Children, we tested whether a PRS for Alzheimer’s disease was associated with trajectories of cardiometabolic risk factors. We examined trajectories for height at 1-18 years; lean and fat mass at 9-18 years; systolic and diastolic blood pressure at 7-18 years; glucose and C-reactive protein at 9-18 years; insulin at 10-18 years; and high and low-density lipoproteins and triglycerides birth at 18 years. We also examined birthweight and interleukin-6 (IL-6) at age 9 years and physical activity at ages 11, 12, and 15 years.ResultsNo consistent associations were observed between the PRS excluding genetic variants in the apolipoprotein E gene region and cardiometabolic factors trajectories across childhood and adolescence.ConclusionsWe did not detect evidence to suggest that the PRS for Alzheimer’s disease acts through childhood and adolescent cardiometabolic risk factors. Further studies should examine whether these associations emerge later in adulthood when variation in cardiometabolic risk factors is likely to be greater.