EFFECT OF AGE, HELICOBACTER-PYLORI INFECTION, AND GASTRITIS WITH ATROPHY ON SERUM GASTRIN AND GASTRIC-ACID SECRETION IN HEALTHY-MEN
EFFECT OF AGE, HELICOBACTER-PYLORI INFECTION, AND GASTRITIS WITH ATROPHY ON SERUM GASTRIN AND GASTRIC-ACID SECRETION IN HEALTHY-MEN
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DOI：
10.1136/gut.34.8.1032
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发表时间：
1993-08-01
期刊：
影响因子：
24.5
通讯作者：
JONES, DB
中科院分区：
文献类型：
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作者：
KATELARIS, PH;SEOW, F;JONES, DB
胃酸分泌一直被认为随着年龄的增长而下降，但随着幽门螺杆菌感染的重要性的出现，这种观点正在被重新评估。本研究旨在确定年龄、幽门螺杆菌和胃炎伴萎缩对健康无症状男性血清胃泌素浓度、胃分泌量和胃酸输出的影响。年轻男性(平均（SD）年龄22.9（0.6）岁；与老年男性(72.9（1.2）岁；N =28)基础血清胃泌素和基础饲粮、假饲粮五胃泌素刺激最大和峰值泌酸。取胃窦、体和基底活检标本，检查组织学和幽门螺杆菌状态（组织学、培养和快速脲酶试验）。22名年轻男性中有3名（13.6%）和28名老年男性中有16名（57.1%）存在幽门螺杆菌相关胃炎。11例老年人胃炎伴萎缩，其中10例幽门螺杆菌阳性。这些受试者的平均血清胃泌素浓度（SD）高于无萎缩的老年受试者和年轻受试者(61-8 (9.2)；40.0 (2 - 9);分别为36.8 (2.3)pmol/l；p
Gastric acid secretion has been considered to decline with increasing age but this view is being re-evaluated as the importance of Helicobacter pylori infection emerges. This study aimed to determine the effect of age, H pylori, and gastritis with atrophy on the serum gastrin concentration, gastric secretory volumes, and acid output in healthy, asymptomatic men. Young men (mean (SD) age 22.9 (0.6) years; n=22) were compared with old men (72.9 (1.2) years; n=28) in respect of basal serum gastrin and basal, sham fed, pentagastrin stimulated maximal and peak acid secretion. Antral, corpus, and fundal biopsy specimens were taken for histology and H pylori status (histology, culture, and rapid urease test). H pylori associated gastritis was present in three of 22 young (13.6%) and 16 of 28 old (57.1%) men. Gastritis with atrophy was present in 11 old subjects, 10 of whom were H pylori positive. These subjects had higher mean (SD) serum gastrin concentrations than old subjects without atrophy and young subjects (61-8 (9.2); 40.0 (2-9); 36.8 (2.3) pmol/l respectively; p