Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer.
Fatty acid synthase expression and its association with clinico-histopathological features in triple-negative breast cancer.
复制标题
DOI：
10.18632/oncotarget.20152
复制
发表时间：
2017-09-26
期刊：
影响因子：
--
通讯作者：
Miquel TP
中科院分区：
文献类型：
--
作者：
Giró-Perafita A;Sarrats A;Pérez-Bueno F;Oliveras G;Buxó M;Brunet J;Viñas G;Miquel TP
三阴性乳腺癌（TNBC）预后较差，没有被批准的靶向治疗。我们之前的研究表明，脂肪酸合成酶（FASN）在一个小的TNBC患者队列中大量表达，其抑制作用与西妥昔单抗在TNBC临床前小鼠模型中协同作用。在这里，我们评估了FASN和EGFR在TNBC患者队列中的表达，并研究了它们的预后作用及其与临床组织病理学特征、内在TNBC亚型和生存的关系。采用免疫组化方法回顾性评价100例原发性TNBC肿瘤中FASN、EGFR、CK5/6和vimentin的表达。FASN表达分为高、低FASN组。EGFR、CK5/6和vimentin表达用于TNBC固有亚型的分类。FASN在大多数TNBC患者中表达，但在该队列中与总生存率或无病生存率无关。高FASN组与阳性节点状态显著相关。FASN在基底样患者中的表达明显高于间充质样患者。50%的肿瘤中EGFR表达阳性，这些患者的DFS较差。总之，我们的研究结果为进一步研究FASN和EGFR表达在更大的TNBC患者队列中的预后作用提供了依据。
Triple-Negative Breast Cancer (TNBC) has poor prognosis and no approved targeted therapy. We previously showed that the enzyme fatty acid synthase (FASN) was largely expressed in a small TNBC patients’ cohort and its inhibition synergized with cetuximab in TNBC preclinical mouse models. Here, we evaluated FASN and EGFR expression in a cohort of TNBC patients and we study their prognostic role and their association with clinico-histopathological features, intrinsic TNBC subtypes and survival. FASN, EGFR, CK5/6 and vimentin expression were retrospective evaluated by Immunohistochemistry in 100 primary TNBC tumors. FASN expression was classified into high and low FASN groups. EGFR, CK5/6 and vimentin expression were used in TNBC intrinsic subtypes classification. FASN was expressed in most of the TNBC patients but did not correlate with overall survival or disease-free survival in this cohort. High FASN group was significantly associated with positive node status. FASN expression was significantly higher in Basal-Like patients than in Mesenchymal-Like ones. EGFR expression was positive in 50% of the tumors, and those patients showed poorer DFS. Altogether, our findings provide a rationale for further investigation the prognostic role of FASN and EGFR expression in a larger cohort of TNBC patients.