Perfusion reserve in asymptomatic individuals.
Perfusion reserve in asymptomatic individuals.
复制标题
无症状个体的灌注储备。
DOI：
10.1007/s10554-004-7032-0
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Jerosch-Herold,Michael
中科院分区：
文献类型：
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作者：
Jerosch-Herold,Michael
The Framingham Heart Study has firmly established the concept of assessing the risk of coronary artery disease (CAD) from risk factors, such as age, sex, blood pressure, cholesterol, diabetes mellitus, and smoking habit. As CAD continues to be the leading cause of mortality and morbidity in the industrialized world, more efforts are being directed at the detection of coronary atherosclerosis, including detection during the early and latent phases when it does not produce clinical symptoms. The underlying premise is that early therapeutic intervention may avoid or delay the onset of overt CAD.Continuous advances in cardiac imaging with modalities such as electron beam and multidetector computed tomography (MDCT), and magnetic resonance imaging (MRI) have produced compelling evidence that it is feasible to image and detect sub-clinical atherosclerosis. Detection of coronary plaque and coronary calcium screening are important examples of these efforts, which may provide a better understanding of the pathophysiology of CAD, and result in superior approaches for detecting CAD during its ‘silent’phase. Coronary artery calcification (CAC), as determined by electron beam tomography, is a marker of coronary artery plaque burden, and a high calcium burden is associated with a high risk of coronary heart disease (CHD). Similarly, the coronary plaque, vulnerable to rupture (‘soft’plaque), even when only causing little or no hemodynamically significant coronary artery lumen narrowing, is known to be an ominous source of thromboembolic events. Measurements of calcium and plaque burden improve risk prediction and stratification for CHD and cardiovascular disease, and thereby one may
