Acupuncture for pilocarpine-resistant xerostomia following radiotherapy for head and neck malignancies
Acupuncture for pilocarpine-resistant xerostomia following radiotherapy for head and neck malignancies
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DOI：
10.1016/s0360-3016(00)01530-3
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发表时间：
2001-06-01
影响因子：
7
通讯作者：
Niemtzow, RC
中科院分区：
文献类型：
--
作者：
Johnstone, PAS;Peng, YP;Niemtzow, RC
目的：口干症是头颈部肿瘤放疗(XRT)后常见的一种潜在的致衰性毒性反应。方法与材料：18例头颈部恶性肿瘤XRT治疗后皮洛卡品治疗无效的口干症患者均采用针灸治疗，所有患者均无原发灶复发的证据。针刺双侧耳穴3个，指穴1个，采用不同的电刺激。结果：针灸对口干症有不同程度的缓解作用，口干症缓解效果从零到强(治疗前减去治疗后20分以上)。有9名患者在XI中受益超过10分，结论：针灸减少了一些患者的口干症，否则这些患者对目前的最佳治疗方案难以接受。(C)2001年爱思唯尔科学公司。
Objective: Xerostomia is a frequent and potentially debilitating toxicity of radiotherapy (XRT) for cancers of the head and neck. This report describes the use of acupuncture as palliation for such patients,Methods and Materials: Eighteen patients with xerostomia refractory to pilocarpine therapy after XRT for head and neck malignancy were offered acupuncture as palliation, All patients are without evidence of cancer recurrence at the primary site. Acupuncture was provided to three auricular points and one digital point bilaterally, with electrostimulation used variably. The Xerostomia Inventory (XI) was administered retrospectively to provide an objective measure of efficacy,Results: Acupuncture contributed to relief from xerostomia to varying degrees, Palliative effect as measured by the XI varied from nil to robust (pre- minus post- therapy values of over 20 points). Nine patients had benefit of over 10 points on the XI,Conclusions: Acupuncture reduces xerostomia in some patients who are otherwise refractory to best current management. (C) 2001 Elsevier Science Inc.