Salivary cortisol and dehydroepiandrosterone sulfate in adolescent rape victims with post traumatic stress disorder
Salivary cortisol and dehydroepiandrosterone sulfate in adolescent rape victims with post traumatic stress disorder
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DOI：
10.1016/j.psyneuen.2012.06.015
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发表时间：
2013-03-01
影响因子：
3.7
通讯作者：
Van de Putte, Elise M.
中科院分区：
文献类型：
--
作者：
Bicanic, Iva A. E.;Postma, Riemke M.;Van de Putte, Elise M.
背景资料：在患有创伤后应激障碍（PTSD）的慢性性虐待受害者中，下丘脑垂体肾上腺（HPA）轴可能失调。在单一的强奸受害者，创伤后应激障碍症状被假设为一种慢性应激源，导致类似的HPA轴失调。本研究的目的是评估HPA轴功能在女性青少年与强奸相关的创伤后应激障碍，但没有以前的性创伤，与非受害对照。方法：对52例女性青少年强奸创伤后应激障碍受害者和37例健康青少年分别于清醒后0、15、30、45和60 min测定唾液皮质醇和硫酸脱氢表雄酮（DHEAS）水平。结果：与年龄匹配的对照组相比，患有PTSD的青少年强奸受害者的皮质醇和DHEAS水平显着降低。地塞米松抑制的效果没有组间差异被发现。无论是强奸和创伤后应激障碍的诊断，而不是因素，如睡眠时间，吸烟，教育或口服避孕药，占强奸受害者和controls.Conclusions之间的神经内分泌差异：结果显示证据的HPA轴失调的女性青少年受害者的单一性创伤与创伤后应激障碍。皮质醇减少症的发现与慢性性虐待受害者的内分泌功能障碍一致，可能对治疗可能性具有临床意义。(C)2012爱思唯尔有限公司保留所有权利。
Background: In chronic sexual abuse victims with post traumatic stress disorder (PTSD), the hypothalamic pituitary adrenal (HPA) axis can be dysregulated. In single rape victims, PTSD symptoms are hypothesized to function as a chronic stressor leading to similar HPA-axis dysregulation. The objective of the current study was to assess HPA-axis functioning in female adolescents with rape-related PTSD, but no prior sexual trauma, in comparison to non-victimized controls.Method: Salivary cortisol and dehydroepiandrosterone sulfate (DHEAS) were measured in 52 female adolescent rape victims with PTSD and 37 healthy adolescents at 0, 15, 30, 45 and 60 min after awakening, both under basal conditions and after 0.5 mg dexamethasone administration.Results: Compared to age-matched controls, adolescent rape victims with PTSD showed significantly reduced cortisol and DHEAS levels. No group differences for the effect of dexamethasone suppression were found. Both the event of rape and PTSD diagnosis, and not factors such as sleep duration, smoking, education or oral contraceptives, accounted for the neuroendocrine differences between rape victims and controls.Conclusions: The results show evidence for a dysregulated HPA-axis in female adolescent victims of single sexual trauma with PTSD. The finding of hypocortisolism is consistent with endocrine dysfunctioning in chronic sexual abuse victims and may have clinical implications with regard to treatment possibilities. (C) 2012 Elsevier Ltd. All rights reserved.