Oleuropein-Rich Diet Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse
Oleuropein-Rich Diet Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse
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DOI：
10.1021/acs.jafc.5b00556
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发表时间：
2015-08-05
影响因子：
6.1
通讯作者：
Nakajima, Yoshihiro
中科院分区：
文献类型：
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作者：
Murotomi, Kazutoshi;Umeno, Aya;Nakajima, Yoshihiro
橄榄苦苷是一种在橄榄叶中大量发现的酚类化合物，对各种疾病都有有益的影响。然而，尚不清楚富含橄榄苦苷的饮食是否对2型糖尿病表型有效。在这项研究中，我们研究了含有橄榄苦苷的补充剂OPIACE（橄榄苦苷含量超过35%（w/w））对2型糖尿病模型Tsumura Suzuki肥胖糖尿病（TSOD）小鼠糖尿病表型的影响。TSOD小鼠在4周龄时喂食OPIACE;即，在TSOD小鼠表现出糖尿病表型之前。我们发现，OPIACE在长期（10 - 24周龄）内减轻了TSOD小鼠的高血糖和糖耐量受损，但对肥胖没有影响。此外，我们证明OPIACE可轻度降低TSOD小鼠的氧化应激26.2%，并减轻老年TSOD小鼠的焦虑样行为异常。结果表明，橄榄苦苷长期抑制2型糖尿病和糖尿病相关行为异常的进展。
Oleuropein, a phenolic compound found in abundance in olive leaves, has beneficial effects on various diseases'. However, it is unknown whether an oleuropein-rich diet is efficacious against type 2 diabetic phenotypes. In this study, we investigated the effects of the oleuropein-containing supplement OPIACE, whose oleuropein content exceeds 35% (w/w), on the diabetic phenotypes in type 2 diabetes model Tsumura Suzuki Obese Diabetes (TSOD) mouse. TSOD mice Were fed OPIACE at 4 weeks of age; i.e., before the TSOD mice exhibited diabetic phenotype. We revealed that OPIACE attenuated hyperglycemia and impaired glucose tolerance in TSOD mice over the long-term (from 10 to 24 weeks of age) but had no effect On obesity. Furthermore, we demonstrated that OPIACE mildly reduced oxidative stress in TSOD mice by 26.2% and attenuated anxiety-like behavioral abnormality in aged TSOD mice. The results suggest that oleuropein suppresses the progression of type 2 diabetes and diabetes-related behavioral abnormality over the long-term.