Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.
Tenascin-C and Integrin α9 Mediate Interactions of Prostate Cancer with the Bone Microenvironment.
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DOI：
10.1158/0008-5472.can-17-0064
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发表时间：
2017-11-01
期刊：
影响因子：
11.2
通讯作者：
Rowley DR
中科院分区：
文献类型：
--
作者：
San Martin R;Pathak R;Jain A;Jung SY;Hilsenbeck SG;Piña-Barba MC;Sikora AG;Pienta KJ;Rowley DR
细胞外基质蛋白tenascin-C的沉积是反应性基质反应的一部分，在前列腺癌的进展中起着关键作用。在这里，我们报道tenascin-C在骨内膜中表达，并参与前列腺骨转移的形成。整合素α9β1介导的转移细胞粘附和集落形成增强。此外，在以受精卵的绒毛膜-尿囊膜为宿主的新型系统中，转移细胞优先迁移和定植腱球蛋白c包被的异种骨移植物。总的来说，我们的研究加深了对骨内膜反应性基质反应的认识，这些反应伴随着前列腺癌转移到小梁骨，这对治疗患者的这一过程具有潜在的意义。
Deposition of the extracellular matrix protein tenascin-C is part of the reactive stroma response, which has a critical role in prostate cancer progression. Here we report that tenascin-C is expressed in the bone endosteum and involved associated with formation of prostate bone metastases. Metastatic cells cultured on osteo-mimetic surfaces coated with tenascin-C exhibited enhanced adhesion and colony formation as mediated by integrin α9β1. Additionally, metastatic cells preferentially migrated and colonized tenascin-C-coated trabecular bone xenografts in a novel system that employed chorioallantoic membranes of fertilized chicken eggs as host. Overall, our studies deepen knowledge about reactive stroma responses in the bone endosteum that accompany prostate cancer metastasis to trabecular bone, with potential implications to therapeutically target this process in patients.