Non-coding RNA in thyroid cancer - Functions and mechanisms
Non-coding RNA in thyroid cancer - Functions and mechanisms
复制标题
甲状腺癌中的非编码RNA - 功能和机制
DOI：
10.1016/j.canlet.2020.08.021
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发表时间：
2021-01-01
期刊：
影响因子：
9.7
通讯作者：
Fang, Meiyu
中科院分区：
文献类型：
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作者：
Cao, Jun;Zhang, Mengdi;Fang, Meiyu
甲状腺癌是最常见的内分泌恶性肿瘤，近年来发病率明显上升。近年来，越来越多的非编码rna （ncRNAs）在人甲状腺癌中显示出异常的表达模式。根据大小的不同，ncrna通常被分为两类：短ncrna和长ncrna（长度超过200个核苷酸）。短ncRNAs包括microRNAs （miRNAs）、piwi相互作用rna、小核核rna和内源性小干扰rna，它们因在发育和肿瘤生物学中的作用而被广泛研究。与短ncrna相比，lncrna在人类癌症，特别是甲状腺癌中的作用尚未得到充分研究。本文综述了mirna、lncrna和环状RNA在甲状腺发育、肿瘤发生和转移中的作用和临床意义，以期为甲状腺癌的治疗提供新的途径。
Thyroid cancer is the most common endocrine malignant tumor, and its incidence has increased significantly in the past few years. A growing number of noncoding RNAs (ncRNAs) have shown abnormal expression patterns in human thyroid cancer in recent studies. Depending on size, ncRNAs are usually subdivided into two categories: short ncRNAs and long ncRNAs (longer than 200 nucleotides). Short ncRNAs include microRNAs (miRNAs), PIWI-interacting RNAs, small nucleolar RNAs, and endogenous small interfering RNAs, which have been extensively studied due to their roles in developmental and tumor biology. Compared to that of short ncRNAs, the involvement of lncRNAs in human cancers, especially in thyroid cancer, is not as well studied. Here, we reviewed the roles and clinical significance of miRNAs, lncRNAs, and circular RNA in thyroid development, tumorigenesis, and metastasis to offer a new approach to thyroid cancer treatment.