Childhood acute lymphoblastic leukemia and infections in the first year of life: A report from the United Kingdom Childhood Cancer Study
Childhood acute lymphoblastic leukemia and infections in the first year of life: A report from the United Kingdom Childhood Cancer Study
复制标题
DOI：
10.1093/aje/kwk039
复制
发表时间：
2007-03-01
影响因子：
5
通讯作者：
Eden, T.
中科院分区：
文献类型：
--
作者：
Roman, E.;Simpson, J.;Eden, T.
英国儿童癌症研究旨在探究儿童癌症与先前感染性疾病暴露之间的关系。作者分析了2 - 5岁急性淋巴细胞白血病（ALL）的诊断（1991 - 1996年）与婴儿期临床诊断的感染之间的关系。几乎所有研究中的儿童（病例组和对照组均为96%）在一岁生日前至少有一次因非免疫相关原因去看全科医生。被诊断患有ALL的儿童在婴儿期临床诊断的感染次数明显多于对照组；感染次数的平均值为3.6次（95%置信区间（CI）：3.3，3.9），而对照组为3.1次（95% CI：2.9，3.2）。这种病例 - 对照差异在新生儿期最为明显（
The United Kingdom Childhood Cancer Study was designed to examine the relation between childhood cancer and preceding exposure to infectious diseases. The authors analyzed the relation between diagnosis (1991-1996) of acute lymphoblastic leukemia (ALL) at ages 2-5 years and clinically diagnosed infections in infancy. Almost all study children (96% of both cases and controls) were taken to a general practitioner for a non-immunization-associated visit at least once before their first birthday. Children diagnosed with ALL had significantly more clinically diagnosed infectious episodes in infancy than did controls; the average number of episodes was 3.6 (95% confidence interval (CI): 3.3, 3.9) versus 3.1 (95% CI: 2.9, 3.2). This case-control difference was most apparent in the neonatal period (