BIOLOGICAL HALF-TIME OF CADMIUM IN THE BLOOD OF WORKERS AFTER CESSATION OF EXPOSURE
BIOLOGICAL HALF-TIME OF CADMIUM IN THE BLOOD OF WORKERS AFTER CESSATION OF EXPOSURE
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DOI：
10.5271/sjweh.2404
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发表时间：
1983-01-01
影响因子：
6.3
通讯作者：
KJELLSTROM, T
中科院分区：
文献类型：
--
作者：
JARUP, L;ROGENFELT, A;KJELLSTROM, T
对既往接触者停止接触后血中镉的生物半衰期进行估算。五名男子被跟踪了10-13年。一室和二室指数消除模型被用来描述血镉水平随时间的下降。用二室模型得到了与数据的最佳拟合度。根据该模型估算的半衰期，快成分为75-128天，慢成分为7.4-16.0年。Cd存在较长的全身生物半衰期，估算的半衰期与不同方法得到的结果基本一致。
The biological half-time of Cd in the blood of previously exposed workers was estimated after the cessation of exposure. Five men were followed for 10-13 yr. One-compartment and 2-compartment exponential elimination models were used to describe the decrease in blood Cd levels over time. The best fit to the data was obtained with a 2-compartment model. The half-times estimated from this model ranged from 75-128 days for the fast component and from 7.4-16.0 yr for the slow component. There was a long whole-body biological half-time for Cd, and the estimated half-times were similar to those obtained with different methods.