Periodontopathogen- and Host-Derived Immune Response in Acute Coronary Syndrome
Periodontopathogen- and Host-Derived Immune Response in Acute Coronary Syndrome
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DOI：
10.1111/j.1365-3083.2011.02584.x
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发表时间：
2011-10-01
影响因子：
3.7
通讯作者：
Pussinen, P. J.
中科院分区：
文献类型：
--
作者：
Alfakry, H.;Paju, S.;Pussinen, P. J.
由于分子模拟，牙周病原体携带可能导致与宿主的系统交叉反应性免疫应答。本研究旨在探讨急性冠状动脉综合征（ACS）患者血清热休克蛋白60（HSP 60）抗体水平与伴放线菌聚集杆菌（Aggregatibacteractinomycetemcomitans）和牙龈卟啉单胞菌（Porphyromonasgingivalis）两种牙周致病菌的抗体水平和唾液携带情况以及患者的牙齿状况之间的关系。ACS患者（n = 141）在入院时的基线、1周、3个月和1年后进行监测。牙周炎状态通过牙科X线片记录，A。在基线时，通过PCR从唾液中检测伴放线菌和牙龈卟啉单胞菌。在所有时间点测定血清IgG和伊加抗体水平。所有抗体水平在随访期间保持相当稳定。血清抗A.伴放线菌与HSP 60在各时间点均呈强正相关（r = 0.4，P < 0.05）。血清HSP 60 IgG抗体水平显著高于对照组。伴放线菌IgG和IgA血清阳性的患者比血清阴性的患者，但病原体携带者与非携带者相比没有差异。HSP60抗体水平无显着差异无牙颌，非牙周炎和牙周炎患者。尽管在系统IgG类抗体应答中观察到对HSP 60和A.伴放线菌感染、唾液携带病原菌及牙周状况对ACS患者HSP 60抗体水平无影响。
Owing to molecular mimicry, periodontal pathogen carriage may result in a systemic cross-reactive immune response with the host. The analyses were performed to investigate if serum antibody levels to human heat shock protein 60 (HSP60) are associated with the antibody levels and salivary carriage of two periodontal pathogens, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, as well as with the dental status in patients with acute coronary syndrome (ACS). ACS patients (n = 141) were monitored at baseline when entering to hospital, and after 1 week, 3 months and 1 year. Periodontal status was recorded by dental radiographs, and A. actinomycetemcomitans and P. gingivalis were detected by PCR from saliva at baseline. Serum IgG and IgA antibody levels were determined at all time points. All antibody levels remained quite stable during the follow-up. Serum IgG-class antibody levels to A. actinomycetemcomitans and HSP60 had a strong positive correlation with each other at all time points (r similar to 0.4, P < 0.05). Mean serum IgG antibody levels to HSP60 were significantly higher in the A. actinomycetemcomitans IgG- and IgA-seropositive than in the seronegative patients, but did not differ between the pathogen carriers compared to the non-carriers. HSP60 antibody levels did not differ significantly between the edentulous, non-periodontitis and periodontitis patients. Despite the observed cross-reactivity in the systemic IgG-class antibody response to HSP60 and A. actinomycetemcomitans, the pathogen carriage in saliva or the periodontal status did not affect the HSP60 antibody levels in ACS patients.