Hyperglucagonemia and hyperkinetic circulation after portocaval shunt in the rat.
Hyperglucagonemia and hyperkinetic circulation after portocaval shunt in the rat.
复制标题
大鼠门静脉分流术后高胰高血糖素血症和高动力循环。
DOI：
--
复制
发表时间：
1987
影响因子：
--
通讯作者：
J. Rodés
中科院分区：
文献类型：
--
作者：
D. Kravetz;M. Arderiu;J. Bosch;J. Fuster;J. Visa;R. Casamitjana;J. Rodés
本研究旨在研究大鼠门腔静脉分流术（PCS）后门静脉流入量（PVI）增加是否是选择性内脏血管舒张的结果，或者是否是全身性循环障碍的一部分。术后2周，通过用放射性微球测量心输出量（CO）、PVI和肝动脉流量（HAF），研究PCS大鼠（n = 9）和假手术对照组（n = 8）。用放射免疫法测定血浆胰高血糖素（GL）。PCS大鼠的CO增加（46.2 +/- 2.8 vs. 28.2 +/- 1.7 ml X min-1 X 100 g-1，P <0.001），动脉压和总外周阻力降低。PVI明显增加（7.7 +/- 0.7 vs. 4.3 +/- 0.2 ml X min-1 X 100 g-1，P <0.001），但这似乎是全身循环障碍的一部分，因为当PVI表示为CO的百分比时，在PCS和假手术大鼠之间没有观察到差异（17.0 +/- 1.5 vs. 15.8 +/-1.3%，NS），表明不存在优先内脏血管舒张。PCS后GL升高（548 +/- 130 vs. 156 +/- 23 pg/ml，P <0.005），GL与CO（r = 0.787，P <0.001）和GL与PVI（r = 0.806，P <0.001）之间存在显著相关性。（250字处删节）
The study was aimed at investigating whether increased portal venous inflow (PVI) after portocaval shunt (PCS) in the rat is the result of selective splanchnic vasodilatation or whether it is part of a generalized circulatory disturbance. Rats with PCS (n = 9) and sham-operated controls (n = 8) were studied 2 wk after surgery by measuring cardiac output (CO), PVI, and hepatic artery flow (HAF) with radioactive microspheres. Plasma glucagon (GL) was measured by radioimmunoassay. PCS rats had increased CO (46.2 +/- 2.8 vs. 28.2 +/- 1.7 ml X min-1 X 100 g-1, P less than 0.001) and reduced arterial pressure and total peripheral resistance. PVI was markedly increased (7.7 +/- 0.7 vs. 4.3 +/- 0.2 ml X min-1 X 100 g-1, P less than 0.001), but this appeared to be part of a generalized circulatory disturbance, since when PVI is expressed as percent of CO no difference is observed between PCS and sham-operated rats (17.0 +/- 1.5 vs. 15.8 +/- 1.3%, NS), indicating the absence of a preferential splanchnic vasodilatation. GL increased after PCS (548 +/- 130 vs. 156 +/- 23 pg/ml, P less than 0.005), and significant correlations were observed between GL and CO (r = 0.787, P less than 0.001) and between GL and PVI (r = 0.806, P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)