Venous and arterial changes in pulmonary veno-occlusive disease, mitral stenosis and fibrosing mediastinitis
Venous and arterial changes in pulmonary veno-occlusive disease, mitral stenosis and fibrosing mediastinitis
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DOI：
10.1034/j.1399-3003.2000.15a21.x
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发表时间：
2000-01-01
影响因子：
24.3
通讯作者：
Meyrick, B
中科院分区：
文献类型：
--
作者：
Chazova, I;Robbins, I;Meyrick, B
肺静脉闭塞性疾病（PVOD）的发病机制尚不清楚。本研究对PVOD（n=5）中发生的肺静脉和肺动脉重塑进行了系统分析，并将这些改变与影响肺静脉的其他两种疾病二尖瓣狭窄（MS; n=6）和纤维化纵隔炎（FM;在PVOD中，在所有大小的静脉中均观察到明显的内膜和外膜增厚，并且发现外径>50 μ m的静脉动脉化。在动脉壁中也观察到类似的变化，但内膜增厚不像静脉那样严重，而中膜增厚在动脉中更为明显
The pathogenesis of pulmonary veno-occlusive disease (PVOD) is not known. The diagnosis of PVOD frequently relies on its histological changes since it is often difficult to distinguish clinically from primary pulmonary hypertension.This study carried out a systematic analysis of the pulmonary venous and arterial remodelling that occurs in PVOD (n=5) and compared these changes to two other diseases affecting the pulmonary veins, mitral stenosis (MS; n=6) and fibrosing mediastinitis (FM; n=2), using established morphometric techniques.In PVOD, pronounced intimal and adventitial thickening were noted in veins of all sizes and arterialization of veins >50 mu m external diameter was found. Similar changes were evident in the arterial wall, but intimal thickening was less severe than in the veins and medial thickening was more pronounced in arteries